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A Bone Replaceable Artificial Bone Substitute: Cytotoxicity, Cell Adhesion, Proliferation, and Alkaline Phosphatase Activity

DC FieldValueLanguage
dc.contributor.author박종철-
dc.contributor.author서활-
dc.date.accessioned2016-02-19T10:54:32Z-
dc.date.available2016-02-19T10:54:32Z-
dc.date.issued2001-
dc.identifier.issn0160-564X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141968-
dc.description.abstractCellular toxicity, cell adhesion and proliferation, and alkaline phosphatase (ALP) activity were investigated for an artificial bone substitute composed of heated carbonate apatite (CAp) and Type I atelocollagen (AtCol) extracted from bovine tail skins (88/12 in %wt/wt). To enhance the intramolecular crosslinking between collagen molecules, the CAp-AtCol substitutes were irradiated by ultraviolet rays (wave length 254 nm) at 4°C for 4 h or vacuum dried at 150°C for 2 h. Cytotoxicity tests by a direct contact method and an extract dilution method revealed that the CAp-AtCol substitutes were cytocompatible for balb 3T3 fibroblasts. Osteoblast adhesion studies demonstrated that the substitute disks composed of 980°C-heated CAp and AtCol were significantly more adhesive for osteoblasts than those of 1,200°C-sintered CAp and AtCol (p < 0.05). Proliferation studies showed that the number of osteoblasts grown in the media containing substitutes of 980°C-heated CAp and AtCol was statistically higher than grown in those of 1,200°C-sintered CAp and AtCol after 5 days (p < 0.05). It was found that osteoblasts grown in the substitutes of 980°C-heated CAp and AtCol only expressed similar ALP activity to the controls. These results suggested that the substitutes consisting of 980°C-heated CAp and AtCol show more favorable interactions with osteoblasts than those of 1,200°C-sintered CAp and AtCol.-
dc.description.statementOfResponsibilityopen-
dc.format.extent14~21-
dc.relation.isPartOfARTIFICIAL ORGANS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA Bone Replaceable Artificial Bone Substitute: Cytotoxicity, Cell Adhesion, Proliferation, and Alkaline Phosphatase Activity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorHwal Suh-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorDong-Wook Han-
dc.contributor.googleauthorDong Hee Lee-
dc.contributor.googleauthorChang Dong Han-
dc.identifier.doi10.1046/j.1525-1594.2001.025001014.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01662-
dc.contributor.localIdA01924-
dc.relation.journalcodeJ00246-
dc.identifier.eissn1525-1594-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1046/j.1525-1594.2001.025001014.x/abstract-
dc.subject.keywordCarbonate apatite-Type latelocollagen substitute-
dc.subject.keywordCytotoxicity-
dc.subject.keywordOsteoblast adhesion-
dc.subject.keywordOseoblast proliferation-
dc.subject.keywordAlkaline phosphatase activity-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameSuh, Hwal-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorSuh, Hwal-
dc.rights.accessRightsnot free-
dc.citation.volume25-
dc.citation.number1-
dc.citation.startPage14-
dc.citation.endPage21-
dc.identifier.bibliographicCitationARTIFICIAL ORGANS, Vol.25(1) : 14-21, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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