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Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis

 Bo Hyon Yun  ;  Young Eun Jeon  ;  Byung Seok Lee  ;  Young Sik Choi  ;  SiHyun Cho  ;  Sun Och Yoon  ;  Joo Hyun Park  ;  Seok Kyo Seo 
 REPRODUCTIVE SCIENCES, Vol.22(12) : 1539-1548, 2015 
Journal Title
Issue Date
Adenomyosis/drug therapy* ; Adenomyosis/metabolism ; Adenomyosis/pathology ; Adenomyosis/physiopathology ; Adult ; Cell Proliferation ; Endometrium/drug effects* ; Endometrium/metabolism ; Endometrium/pathology ; Endometrium/secretion ; Female ; Humans ; Immunohistochemistry ; Intrauterine Devices* ; Levonorgestrel/administration & dosage* ; Nuclear Receptor Coactivator 2/metabolism* ; Nuclear Receptor Coactivator 3/metabolism* ; Retrospective Studies ; Signal Transduction/drug effects
LNG-IUS ; coregulator-related disease ; steroid receptor coregulator
Although the pathophysiology of adenomyosis has not been clarified, it is thought to be related to ectopic endometrium, which depends on hormonal regulation. The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective for the medical treatment of adenomyosis. However, the underlying molecular mechanisms by which LNG-IUS ameliorates adenomyosis pathology remain unclear. This study was designed to compare the expression levels of steroid receptor coregulators in human endometrium of control and participants with adenomyosis and to determine whether LNG-IUS modulated their expression. Immunohistochemistry with H-scores was performed. Steroid receptor coactivators were shown to have significantly decreased expressions at the secretory phase in the LNG-IUS group when compared to the other groups. Expression of transcriptional intermediary factor 2 was lower in the LNG-IUS group than in both the control group (P = .015) and the untreated adenomyosis group (P = .019) during the secretory phase. Amplified in breast cancer 1 expression was higher in the stromal cells of the untreated adenomyosis group than in those of the controls (P = .017) during the secretory phase; however, levels were lower in the LNG-IUS group (P = .005). Nuclear receptor corepressor expression increased during the proliferative phase and decreased during the secretory phase in untreated adenomyosis; this pattern was reversed in the control and LNG-IUS groups. Thus, an altered expression of steroid receptor coregulators may play a role in adenomyosis development and treatment.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joo Hyun(박주현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Jeon, Young Eun(전영은)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
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