Cited 13 times in
Negative Impact of Aromatase Inhibitors on Proximal Femoral Bone Mass and Geometry in Postmenopausal Women with Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 노윤호 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이수진 | - |
dc.date.accessioned | 2016-02-04T12:02:54Z | - |
dc.date.available | 2016-02-04T12:02:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0171-967X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141774 | - |
dc.description.abstract | Aromatase inhibitors (AIs), the standard therapy for estrogen receptor- or progesterone receptor-positive breast cancer in postmenopausal women, lead to increased hip fractures in breast cancer patients. To investigate the mechanism of increased incidence of hip fractures in breast cancer patients treated with AIs, we evaluated bone mineral density (BMD) in the cortical and trabecular compartments and assessed femoral geometry using quantitative computed tomography (QCT) in breast cancer patients. In total, 249 early breast cancer patients who underwent QCT in their fifties (mean age 54.3 years) were retrospectively analyzed. Proximal femoral BMD and geometrical parameters were compared. In all regions of the proximal femur, cortical areal BMDs were lower in the AI group than in the non-AI group (p < 0.05). Cortical thickness of the femoral neck, trochanter, and total hip was significantly lower in the AI group compared with the non-AI group (p < 0.05). Analysis of the narrowest section of the femoral neck showed significantly thinner cortical bone and smaller cortical area in the AI group than in the non-AI group (p < 0.05), especially in the superoposterior quadrant. Bone strength parameters in the femoral neck, such as the section modulus and cross-sectional moment of inertia, were significantly lower in the AI group than in the non-AI group (p < 0.05). In conclusion, AI treatment in breast cancer patients is associated with deterioration of femoral cortical BMD and geometry, which could contribute in site-specific weakened bone strength and increased incidence of hip fractures. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 551~559 | - |
dc.relation.isPartOf | CALCIFIED TISSUE INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aromatase Inhibitors/adverse effects* | - |
dc.subject.MESH | Bone Density/drug effects | - |
dc.subject.MESH | Breast Neoplasms/drug therapy* | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Femur Neck/diagnostic imaging* | - |
dc.subject.MESH | Femur Neck/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postmenopause | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Negative Impact of Aromatase Inhibitors on Proximal Femoral Bone Mass and Geometry in Postmenopausal Women with Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Su Jin Lee | - |
dc.contributor.googleauthor | Kyoung Min Kim | - |
dc.contributor.googleauthor | J. Keenan Brown | - |
dc.contributor.googleauthor | Alan Brett | - |
dc.contributor.googleauthor | Yun Ho Roh | - |
dc.contributor.googleauthor | Dae Ryong Kang | - |
dc.contributor.googleauthor | Byeong Woo Park | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1007/s00223-015-0046-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01287 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A02894 | - |
dc.relation.journalcode | J00425 | - |
dc.identifier.eissn | 1432-0827 | - |
dc.identifier.pmid | 26232103 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00223-015-0046-x | - |
dc.subject.keyword | Aromatase inhibitor | - |
dc.subject.keyword | Bone geometry | - |
dc.subject.keyword | Bone strength | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Quantitative computed tomography | - |
dc.contributor.alternativeName | Roh, Yun Ho | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Roh, Yun Ho | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 97 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 551 | - |
dc.citation.endPage | 559 | - |
dc.identifier.bibliographicCitation | CALCIFIED TISSUE INTERNATIONAL, Vol.97(6) : 551-559, 2015 | - |
dc.identifier.rimsid | 30878 | - |
dc.type.rims | ART | - |
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