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Role of transcription factor acetylation in the regulation of metabolic homeostasis

Authors
 Joo-Man Park  ;  Seong-Ho Jo  ;  Mi-Young Kim  ;  Tae-Hyun Kim  ;  Yong-Ho Ahn 
Citation
 PROTEIN & CELL, Vol.6(11) : 804-813, 2015 
Journal Title
 PROTEIN & CELL 
ISSN
 1674-800X 
Issue Date
2015
MeSH
Acetylation ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Homeostasis/genetics ; Homeostasis/physiology ; Humans ; Protein Processing, Post-Translational/genetics ; Protein Processing, Post-Translational/physiology ; Transcription Factors/metabolism*
Keywords
metabolic homeostasis ; post-translational modification ; transcription factor ; type 2 diabetes mellitus
Abstract
Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.
Files in This Item:
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DOI
10.1007/s13238-015-0204-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Young(김미영)
Kim, Tae Hyun(김태현)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141771
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