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Role of transcription factor acetylation in the regulation of metabolic homeostasis

Authors
 Joo-Man Park ; Seong-Ho Jo ; Yong-Ho Ahn ; Tae-Hyun Kim ; Mi-Young Kim 
Citation
 Protein & Cell, Vol.6(11) : 804~813, 2015 
Journal Title
 Protein & Cell 
ISSN
 1674-800X 
Issue Date
2015
Abstract
Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141771
DOI
10.1007/s13238-015-0204-y
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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