51 73

Cited 0 times in

Regression and progression of microalbuminuria in adolescents with childhood onset diabetes mellitus

Authors
 Mi Kyung Son  ;  Ha Young Yoo  ;  Byung Ok Kwak  ;  Hye Won Park  ;  Kyo Sun Kim  ;  Sochung Chung  ;  Hyun Wook Chae  ;  Ho-Seong Kim  ;  Duk Hee Kim 
Citation
 Annals of Pediatric Endocrinology & Metabolism, Vol.20(1) : 13-20, 2015 
Journal Title
 Annals of Pediatric Endocrinology & Metabolism 
ISSN
 2287-1012 
Issue Date
2015
Abstract
PURPOSE: Although microalbuminuria is considered as an early marker of nephropathy in diabetic adults, available information in diabetic adolescents is limited. The aim of this study was to investigate prevalence and frequency of regression of microalbuminuria in type 1 (T1DM) and type 2 diabetes mellitus (T2DM) patients with childhood onset. METHODS: One hundred and nine adolescents (median, 18.9 years; interquartile range (IQR), 16.5-21.0 years) with T1DM and 18 T2DM adolescents (median, 17.9 years; IQR, 16.8-18.4 years) with repeated measurements of microalbuminuria (first morning urine microalbumin/creatinine ratios) were included. The median duration of diabetes was 10.1 (7.8-14.0) years and 5.0 (3.5-5.6) years, respectively, and follow-up period ranged 0.5-7.0 years. Growth parameters, estimated glomerular filtration rate, glycosylated hemoglobin (HbA1c) and lipid profiles were obtained after reviewing medical record in each subject. RESULTS: The prevalence of microalbuminuria at baseline and evaluation were 21.1% and 17.4% in T1DM, and 44.4% and 38.9% in T2DM. Regression of microalbuminuria was observed in 13 T1DM patients (56.5%) and 3 T2DM patients (37.5%), and progression rate was 10.5% and 20% in T1DM and T2DM respectively. In regression T1DM group, HbA1c at baseline and follow-up was lower, and C-peptide at baseline was higher compared to persistent or progression groups. In T2DM, higher triglyceride was observed in persistent group. CONCLUSION: Considerable regression of microalbuminuria more than progression in diabetes adolescents indicates elevated urinary microalbumin excretion in a single test does not imply irreversible diabetic nephropathy. Careful monitoring and adequate intervention should be emphasized in adolescents with microalbuminuria to prevent rapid progression toward diabetic nephropathy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141655
DOI
10.6065/apem.2015.20.1.13
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김호성(Kim, Ho Seong) ; 채현욱(Chae, Hyun Wook)
사서에게 알리기
  feedback
Files in This Item:
T201504105.pdf Download
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse