162 254

Cited 10 times in

Effect of Subthalamic Deep Brain Stimulation on Levodopa-Induced Dyskinesia in Parkinson's Disease

 Ji Hee Kim  ;  Won Seok Chang  ;  Hyun Ho Jung  ;  Jin Woo Chang 
 YONSEI MEDICAL JOURNAL, Vol.56(5) : 1316-1321, 2015 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/adverse effects* ; Deep Brain Stimulation* ; Dyskinesia, Drug-Induced/therapy* ; Female ; Humans ; Levodopa/administration & dosage ; Levodopa/adverse effects* ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Parkinson Disease/drug therapy* ; Postoperative Period ; Retrospective Studies ; Subthalamic Nucleus ; Treatment Outcome
Deep brain stimulation ; Parkinson disease ; dyskinesias ; subthalamic nucleus
PURPOSE: To evaluate the effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on levodopa-induced peak-dose dyskinesia in patients with Parkinson's disease (PD). MATERIALS AND METHODS: A retrospective review was conducted on patients who underwent STN DBS for PD from May 2000 to July 2012. Only patients with levodopa-induced dyskinesia prior to surgery and more than 1 year of available follow-up data after DBS were included. The outcome measures included the dyskinesia subscore of the Unified Parkinson's Disease Rating Scale (UPDRS) part IV (items 32 to 34 of UPDRS part IV) and the levodopa equivalent daily dose (LEDD). The patients were divided into two groups based on preoperative to postoperative LEDD change at 12 months after the surgery: Group 1, LEDD decrease >15%; Group 2, all other patients. Group 2 was further divided by the location of DBS leads. RESULTS: Of the 100 patients enrolled, 67 were in Group 1, while those remaining were in Group 2. Twelve months after STN DBS, Groups 1 and 2 showed improvements of 61.90% and 57.14%, respectively, in the dyskinesia subscore. Group 1 was more likely to experience dyskinesia suppression; however, the association between the groups and dyskinesia suppression was not statistically significant (p=0.619). In Group 2, dyskinesia was significantly decreased by stimulation of the area above the STN in 18 patients compared to stimulation of the STN in 15 patients (p=0.048). CONCLUSION: Levodopa-induced dyskinesia is attenuated by STN DBS without reducing the levodopa dosage.
Files in This Item:
T201504104.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hee(김지희)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.