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Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson's Disease

Authors
 Jae Jung Lee ; Jee Hyun Ham ; Young H Sohn ; Phil Hyu Lee 
Citation
 Journal of Movement Disorders, Vol.8(3) : 130~135, 2015 
Journal Title
 Journal of Movement Disorders 
ISSN
 2005-940X 
Issue Date
2015
Abstract
OBJECTIVE:Gender differences are a well-known clinical characteristic of Parkinson's disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibit more rapid aging-related striatal DAT reduction than do men, as the potential neuroprotective effect of estrogen wanes with age. METHODS:This study included 307 de novo PD patients (152 men and 155 women) who underwent DAT scans for an initial diagnostic work-up. Gender differences in age-related DAT decline were assessed in striatal sub-regions using linear regression analysis. RESULTS:Female patients exhibited greater DAT activity compared with male patients in all striatal sub-regions. The linear regression analysis revealed that age-related DAT decline was greater in the anterior and posterior caudate, and the anterior putamen in women compared with men; we did not observe this difference in other sub-regions. CONCLUSIONS:This study demonstrated the presence of gender differences in age-related DAT decline in striatal sub-regions, particularly in the antero-dorsal striatum, in patients with PD, presumably due to aging-related decrease in estrogen. Because this difference was not observed in the sensorimotor striatum, this finding also suggests that women may not have a greater capacity to tolerate PD pathogenesis than do men.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141638
DOI
10.14802/jmd.15031
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
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