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Characteristics and Survival of Breast Cancer Patients with Multiple Synchronous or Metachronous Primary Cancers

 Janghee Lee  ;  Seho Park  ;  Sanghwa Kim  ;  Jeeye Kim  ;  Jegyu Ryu  ;  Hyung Seok Park  ;  Seung Il Kim  ;  Byeong-Woo Park 
 YONSEI MEDICAL JOURNAL, Vol.56(5) : 1213-1220, 2015 
Journal Title
Issue Date
Adult ; Aged ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/mortality* ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Neoplasm Metastasis ; Neoplasm Staging ; Neoplasms, Multiple Primary/diagnosis ; Neoplasms, Multiple Primary/mortality* ; Neoplasms, Second Primary/diagnosis ; Neoplasms, Second Primary/mortality* ; Prognosis ; Quality of Life* ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Analysis
Breast cancer ; metachronous ; multiple primary neoplasms ; survival ; synchronous
PURPOSE: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. MATERIALS AND METHODS: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of ≤5 and >5 years were investigated using univariate and multivariate analyses. RESULTS: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5%) were detected. Synchronous and metachronous MPCs were identified in 23.8% and 79.0% of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At ≤5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. CONCLUSION: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
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