Cited 7 times in
Total Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박광균 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2016-02-04T11:56:47Z | - |
dc.date.available | 2016-02-04T11:56:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141550 | - |
dc.description.abstract | Novel saponins that retain a free carboxyl group at the C-17 position and various sugars linked at the C-3 position of hederagenin aglycone were synthesized via stereospecific glycosylation. Since these natural products represented by Pulsatilla saponin D (PSD) were obtained in very small amounts, the total synthesis developed in this paper will resolve this problem of scarcity. The two types of synthesized arabinose- and rhamnose-cored saponins showed potent anticancer activity against a human lung cancer cell line (A549), and most disaccharide moiety saponins possessed more potent anti-lung cancer activity. Among the novel PSD analogues containing disaccharide saponins, compound 10i showed anti-lung cancer activity (6.6 µM) that was four-fold more potent than the clinical agent Iressa (26.08 µM). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 669~677 | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/chemical synthesis | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/chemistry | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Screening Assays, Antitumor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MCF-7 Cells | - |
dc.subject.MESH | Molecular Structure | - |
dc.subject.MESH | Saponins/chemical synthesis | - |
dc.subject.MESH | Saponins/chemistry | - |
dc.subject.MESH | Saponins/pharmacology* | - |
dc.subject.MESH | Structure-Activity Relationship | - |
dc.title | Total Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Minkyu Kim | - |
dc.contributor.googleauthor | Yongseo Park | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Mankil Jung | - |
dc.identifier.doi | 10.1248/cpb.c15-00106 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A03676 | - |
dc.relation.journalcode | J00509 | - |
dc.identifier.eissn | 1347-5223 | - |
dc.identifier.pmid | 26329860 | - |
dc.subject.keyword | Pulsatilla saponin D | - |
dc.subject.keyword | total synthesis | - |
dc.subject.keyword | stereospecific glycosylation | - |
dc.subject.keyword | hederagenin | - |
dc.subject.keyword | anticancer activity | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 669 | - |
dc.citation.endPage | 677 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, Vol.63(9) : 669-677, 2015 | - |
dc.identifier.rimsid | 30716 | - |
dc.type.rims | ART | - |
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