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Total Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues

DC FieldValueLanguage
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.date.accessioned2016-02-04T11:56:47Z-
dc.date.available2016-02-04T11:56:47Z-
dc.date.issued2015-
dc.identifier.issn0009-2363-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141550-
dc.description.abstractNovel saponins that retain a free carboxyl group at the C-17 position and various sugars linked at the C-3 position of hederagenin aglycone were synthesized via stereospecific glycosylation. Since these natural products represented by Pulsatilla saponin D (PSD) were obtained in very small amounts, the total synthesis developed in this paper will resolve this problem of scarcity. The two types of synthesized arabinose- and rhamnose-cored saponins showed potent anticancer activity against a human lung cancer cell line (A549), and most disaccharide moiety saponins possessed more potent anti-lung cancer activity. Among the novel PSD analogues containing disaccharide saponins, compound 10i showed anti-lung cancer activity (6.6 µM) that was four-fold more potent than the clinical agent Iressa (26.08 µM).-
dc.description.statementOfResponsibilityopen-
dc.format.extent669~677-
dc.relation.isPartOfCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents, Phytogenic/chemical synthesis-
dc.subject.MESHAntineoplastic Agents, Phytogenic/chemistry-
dc.subject.MESHAntineoplastic Agents, Phytogenic/pharmacology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDrug Screening Assays, Antitumor-
dc.subject.MESHHumans-
dc.subject.MESHMCF-7 Cells-
dc.subject.MESHMolecular Structure-
dc.subject.MESHSaponins/chemical synthesis-
dc.subject.MESHSaponins/chemistry-
dc.subject.MESHSaponins/pharmacology*-
dc.subject.MESHStructure-Activity Relationship-
dc.titleTotal Synthesis and Anticancer Activity of Novel Pulsatilla Saponin D Analogues-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorMinkyu Kim-
dc.contributor.googleauthorYongseo Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorMankil Jung-
dc.identifier.doi10.1248/cpb.c15-00106-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ00509-
dc.identifier.eissn1347-5223-
dc.identifier.pmid26329860-
dc.subject.keywordPulsatilla saponin D-
dc.subject.keywordtotal synthesis-
dc.subject.keywordstereospecific glycosylation-
dc.subject.keywordhederagenin-
dc.subject.keywordanticancer activity-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.rights.accessRightsfree-
dc.citation.volume63-
dc.citation.number9-
dc.citation.startPage669-
dc.citation.endPage677-
dc.identifier.bibliographicCitationCHEMICAL & PHARMACEUTICAL BULLETIN, Vol.63(9) : 669-677, 2015-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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