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Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses

Authors
 Soo Jin Chang  ;  Ji Hyun Lee  ;  Shin Hye Kim  ;  Joon Soo Lee  ;  Heung Dong Kim  ;  Joon Won Kang  ;  Young Mock Lee  ;  Hoon Chul Kang 
Citation
 Korean Journal of Pediatrics, Vol.58(5) : 194-198, 2015 
Journal Title
 Korean Journal of Pediatrics 
ISSN
 1738-1061 
Issue Date
2015
Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronically progressive or relapsing symmetric sensorimotor disorder presumed to occur because of immunologic antibody-mediated reactions. To understand the clinical courses of CIDP, we report variable CIDP courses in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. Four patients who were diagnosed with acute-onset and relapsing CIDP courses at Severance Children's Hospital, Seoul, Korea, were enrolled in this retrospective study. We diagnosed each patient on the basis of the CIDP diagnostic criteria developed in 2010 by the European Federation of Neurological Societies/Peripheral Nerve Society Guidelines. We present the cases of four pediatric patients diagnosed with CIDP to understand the variable clinical course of the disease in children. Our four patients were all between 8 and 12 years of age. Patients 1 and 2 were diagnosed with acute cerebellar ataxia or Guillain-Barré syndrome as initial symptoms. While patients 1 and 4 were given only intravenous dexamethasone (0.3 mg/kg/day) for 5 days at the first episode, Patients 2 and 3 were given a combination of intravenous immunoglobulin (2 g/kg) and dexamethasone (0.3 mg/kg/day). All patients were maintained with oral prednisolone at 30 mg/day, but their clinical courses were variable in both relapse intervals and severity. We experienced variable clinical courses of CIDP in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141547
DOI
10.3345/kjp.2015.58.5.194
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
강훈철(Kang, Hoon Chul) ; 김흥동(Kim, Heung Dong) ; 이영목(Lee, Young Mock) ; 이준수(Lee, Joon Soo) ; 이지현(Lee, Ji Hyun)
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