Cited 8 times in
Catheter Ablation of Atrial Fibrillation Raises the Plasma Level of NGF-β Which Is Associated with Sympathetic Nerve Activity
DC Field | Value | Language |
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dc.contributor.author | 박희남 | - |
dc.contributor.author | 위진 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 홍성유 | - |
dc.date.accessioned | 2016-02-04T11:56:39Z | - |
dc.date.available | 2016-02-04T11:56:39Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141545 | - |
dc.description.abstract | PURPOSE: The expression of nerve growth factor-β (NGF-β) is related to cardiac nerve sprouting and sympathetic hyper innervation. We investigated the changes of plasma levels of NGF-β and the relationship to follow-up heart rate variability (HRV) after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). MATERIALS AND METHODS: This study included 147 patients with AF (117 men, 55.8±11.5 years, 106 paroxysmal AF) who underwent RFCA. The plasma levels of NGF-β were quantified using double sandwich enzyme linked immunosorbent assay method before (NGF-β(pre)) and 1 hour after RFCA (NGF-β(post-1hr)). HRV at pre-procedure (HRV(pre)), 3 months (HRV(post-3mo)), and 1 year post-procedure (HRV(post-1yr)) were analyzed and compared with plasma levels of NGF-β. RESULTS: 1) The plasma levels of NGF-β significantly increased after RFCA (20.05±11.09 pg/mL vs. 29.60±19.43 pg/mL, p<0.001). The patients who did not show increased NGF-β(post-1hr) were older (p=0.023) and had greater left atrial volume index (p=0.028) than those with increased NGF-β(post-1hr). 2) In patients with NGF-β(pre) >18 pg/mL, low frequency components (LF)/high-frequency components (HF) (p=0.003) and the number of atrial premature contractions (APCs, p=0.045) in HRV(post-3mo) were significantly higher than those with ≤18 pg/mL. 3) The LF/HF at HRV(post-3mo) was linearly associated with the NGF-β(pre) (B=4.240, 95% CI 1.114-7.336, p=0.008) and the NGF-β(post-1hr) (B=7.617, 95% CI 2.106-13.127, p=0.007). 4) Both NGF-β(pre) (OR=1.159, 95% CI 1.045-1.286, p=0.005) and NGF-β(post-1hr) (OR=1.098, 95% CI 1.030-1.170, p=0.004) were independent predictors for the increase of LF/HF at HRV(post-3mo). CONCLUSION: AF catheter ablation increases plasma level of NGF-β, and high plasma levels of NGF-β(pre) was associated with higher sympathetic nerve activity and higher frequency of APCs in HRV(post-3mo). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1530~1537 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Catheter Ablation of Atrial Fibrillation Raises the Plasma Level of NGF-β Which Is Associated with Sympathetic Nerve Activity | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) | - |
dc.contributor.googleauthor | Jae Hyung Park | - |
dc.contributor.googleauthor | Sung Yu Hong | - |
dc.contributor.googleauthor | Jin Wi | - |
dc.contributor.googleauthor | Da Lyung Lee | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Moon Hyoung Lee | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.3349/ymj.2015.56.6.1530 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02450 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A04400 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.subject.keyword | Atrial fibrillation | - |
dc.subject.keyword | catheter ablation | - |
dc.subject.keyword | nerve growth factor | - |
dc.subject.keyword | sympathetic nerve | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Wi, Jin | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.alternativeName | Hong, Sung Yu | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Wi, Jin | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Hong, Sung Yu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1530 | - |
dc.citation.endPage | 1537 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.56(6) : 1530-1537, 2015 | - |
dc.identifier.rimsid | 30712 | - |
dc.type.rims | ART | - |
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