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Inflammatory Bowel Disease Cohort Studies in Korea: Present and Future

Authors
 Jung Won Lee  ;  Jong Pil Im  ;  Jae Hee Cheon  ;  You Sun Kim  ;  Joo Sung Kim  ;  Dong Soo Han 
Citation
 Intestinal Research, Vol.13(3) : 213-218, 2015 
Journal Title
 Intestinal Research 
ISSN
 1598-9100 
Issue Date
2015
Abstract
Inflammatory bowel disease (IBD) is defined as a chronic and relapsing inflammatory disorder of the intestine. Intestinal inflammation in IBD has been proposed to be attributable to the interplay between microbial, genetic, environmental, and immunological factors. The incidence and prevalence rates of IBD are rapidly increasing apparently in other parts of the world, with dramatic increases especially in East Asia. Generally, cohort studies are useful for estimating the incidence, prevalence, natural course, prognosis, and risk factors of diseases. In particular, cohort studies performed in Western countries have well described the prevalence, risk factors, and natural course of IBD and investigated its genetic pathophysiology. However, the outcomes of IBD cohort studies performed in Korea are not as persuasive as those of Western studies because of the relatively low prevalence of IBD and short follow-up periods of the cohorts in Korea. Despite this critical limitation, members of the Korean Association for the Study of Intestinal Diseases have demonstrated outstanding results. Some unique features of IBD patients in Korea are well demonstrated, such as thiopurine-induced leukopenia or risks of opportunistic tuberculosis infection in patients receiving tumor necrosis factor-α inhibitors. In this review, the present authors summarized the key points of the results of the cohort studies performed in Korea and explored future perspectives
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141530
DOI
10.5217/ir.2015.13.3.213
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
천재희(Cheon, Jae Hee)
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