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간세포암종의 자연퇴행

Other Titles
 Spontaneous neoplastic remission of hepatocellular carcinoma 
 김성배  ;  강원석  ;  신승환  ;  이희승  ;  이상훈  ;  최기홍  ;  박준용 
 Korean Journal of Gastroenterology, Vol.65(5) : 312-315, 2015 
Journal Title
 Korean Journal of Gastroenterology 
Issue Date
Carcinoma, Hepatocellular/diagnosis* ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Hepatitis B/complications ; Hepatitis B/diagnosis ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/etiology ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Necrosis ; Radiography ; Remission, Spontaneous ; Ultrasonography ; alpha-Fetoproteins/analysis
Spontaneous neoplasm regression ; Liver neoplasms ; Spontaneous neoplasm remission
We report on a case of a 57-year-old male who underwent a curative resection for hepatocellular carcinoma (HCC) with histological confirmation of a spontaneously necrotized tumor. Initial serum AFP level was 4,778 ng/mL. A 3.7 cm hyperechoic mass in segment 6 of the liver was observed on ultrasonography and dynamic contrast-enhanced liver MRI showed a 3.7 × 3.1 cm sized HCC. He was scheduled to undergo curative surgical resection under the clinical diagnosis of an early stage HCC (Barcelona Clinic Liver Cancer stage A). Without treatment, the serum AFP level declined rapidly to 50 ng/mL over five weeks. He underwent curative wedge resection of segment 6 of the liver. Histology revealed complete necrosis of the mass rimmed by inflamed fibrous capsule on a background of HBV-related cirrhosis with infiltration of lymphoplasma cells. Exact pathophysiology underlying this event is unknown. Among the proposed mechanisms of spontaneous neoplastic remission of HCC, circulatory disturbance and activation of host immune response offer the most scientific explanation for the complete histologic necrosis of HCC in the resected mass seen in our patient.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Lee, Sang Hoon(이상훈B) ORCID logo https://orcid.org/0000-0002-3619-4340
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
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