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Expectorant and antitussive effect of Hedera helix and Rhizoma coptidis extracts mixture

 Kee Jae Song  ;  Young-June Shin  ;  Kang Ro Lee  ;  Eun Jung Lee  ;  Yun Suk Suh  ;  Kyung-Su Kim 
 YONSEI MEDICAL JOURNAL, Vol.56(3) : 819-824, 2015 
Journal Title
Issue Date
Animals ; Antitussive Agents/administration & dosage* ; Antitussive Agents/pharmacology ; Antitussive Agents/therapeutic use ; Behavior, Addictive* ; Cough/drug therapy* ; Drugs, Chinese Herbal/administration & dosage* ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Ethanol ; Expectorants/administration & dosage* ; Expectorants/pharmacology ; Expectorants/therapeutic use ; Guinea Pigs ; Hedera/chemistry* ; Hedera/metabolism ; Male ; Mice ; Phytotherapy ; Plant Extracts/pharmacology* ; Plant Roots/chemistry ; Trachea/drug effects ; Trachea/metabolism
Hedera helix ; Rhizoma coptidis ; antitussive agent ; expectorant
PURPOSE: This study aims to investigate the additive effect of the Hedera helix (HH) and Rhizoma coptidis (RC) extracts mixture on antitussive and expectorant activities in animals. MATERIALS AND METHODS: The expectorant assay was performed with phenol red secretion in mice trachea. Mice or guinea pigs were randomly divided into groups of 8 each, including negative and positive control groups. After gastric administration of the test extracts in mice, 2.5% phenol red solution (0.2 mL) was intraperitoneally injected. Trachea was dissected and optical density of tracheal secretion was measured. After gastric administration of the test extracts in guinea pigs, the antitussive activities were assessed using a citric acid-induced cough measurement. RESULTS: The extracts of HH and RC significantly increased tracheal secretion and inhibited cough. The mixture of HH and RC extracts in a 1:1 concentration at a dose of 200 mg/kg showed a more potent effect on phenol red secretion (25.25±3.14) and cough inhibition (61.25±5.36) than the individual use of each extracts [phenol red secretion; HH 13.39±4.22 (p=0.000), RC 20.78±2.50 (p=0.010), cough inhibition; HH 9.89±4.14 (p=0.010), RC 30.25±7.69 (p=0.000)]. A 3:1 ratio mixture of HH to RC demonstrated an optimal expectorant effect (p<0.001), and this mixture showed expectorant and antitussive effects in a dose-dependent manner. CONCLUSION: This study provides evidence for antitussive and expectorant effect of a 3:1 mixture of HH and RC, which may be a useful therapeutic option for respiratory diseases.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Song, Kee Jae(송기재)
Lee, Eun Jung(이은정) ORCID logo https://orcid.org/0000-0002-0454-4510
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