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Conventional versus Analgesia-Oriented Combination Sedation on Recovery Profiles and Satisfaction after ERCP: A Randomized Trial

 Seokyung Shin  ;  Tak Geun Oh  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Seung Woo Park  ;  Jae Bok Chung  ;  Si Young Song  ;  Jooyoun Cho  ;  Sang-Hun Park  ;  Young Chul Yoo  ;  Seungmin Bang 
 PLOS ONE, Vol.10(9) : e0138422, 2015 
Journal Title
Issue Date
Aged ; Anesthesia Recovery Period* ; Anesthesia, Intravenous ; Blood Pressure ; Cholangiopancreatography, Endoscopic Retrograde* ; Conscious Sedation*/methods ; Deep Sedation*/methods ; Female ; Humans ; Male ; Middle Aged ; Pain Measurement ; Patient Satisfaction* ; Propofol/administration & dosage ; Respiratory Rate ; Risk Factors
BACKGROUND: The importance of providing effective analgesia during sedation for complex endoscopic procedures has been widely recognized. However, repeated administration of opioids in order to achieve sufficient analgesia may carry the risk of delayed recovery after propofol based sedation. This study was done to compare recovery profiles and the satisfaction of the endoscopists and patients between conventional balanced propofol sedation and analgesia-oriented combination sedation for patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). METHODS: Two hundred and two adult patients scheduled for ERCP were sedated by either the Conventional (initial bolus of meperidine with propofol infusion) or Combination (repeated bolus doses of fentanyl with propofol infusion) method. Recovery profiles, satisfaction levels of the endoscopists and patients, drug requirements and complications were compared between groups. RESULTS: Patients of the Combination Group required significantly less propofol compared to the Conventional Group (135.0 ± 68.8 mg vs. 165.3 ± 81.7 mg, P = 0.005). Modified Aldrete scores were not different between groups throughout the recovery period, and recovery times were also comparable between groups. Satisfaction scores were not different between the two groups in both the endoscopists and patients (P = 0.868 and 0.890, respectively). CONCLUSIONS: Considering the significant reduction in propofol dose, the non-inferiority of recovery profiles and satisfaction scores of the endoscopists and patients, analgesia oriented combination sedation may be a more safe yet effective sedative method compared to conventional balanced propofol sedation during ERCP.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Shin, Seokyung(신서경) ORCID logo https://orcid.org/0000-0002-2641-0070
Oh, Tak Geun(오탁근)
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Chung, Jae Bock(정재복)
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