Cited 25 times in
Na(+)-Ca(2+) exchanger targeting miR-132 prevents apoptosis of cardiomyocytes under hypoxic condition by suppressing Ca(2+) overload
DC Field | Value | Language |
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dc.contributor.author | 서향희 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 이지윤 | - |
dc.contributor.author | 홍순창 | - |
dc.date.accessioned | 2016-02-04T11:52:33Z | - |
dc.date.available | 2016-02-04T11:52:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141396 | - |
dc.description.abstract | During ischemia-reperfusion (IR) injury of the heart, Ca(2+) overload occurs, leading to cardiomyocyte dysfunction and eventual cell death by apoptosis. Since preventing Ca(2+) overload during IR injury has been reported to protect cardiomyocytes, interrupting Ca(2+) signaling cascades leading to Ca(2+) overload may exert protective effect on cardiomyocytes under hypoxic condition. One of the key regulators of the intracellular Ca(2+) level during IR injury is Na(+)-Ca(2+) exchanger 1 (NCX1), whose down-regulation during IR injury conferred protection of heart. In the present study, we examined whether down-regulation of NCX1 using exogenous microRNA ameliorates apoptosis of cardiomyocytes under hypoxic condition. Here, we identified miR-132 as a novel microRNA targeting the NCX1, whose expression increased during hypoxia. Delivery of miR-132 suppressed the increase of intracellular Ca(2+) in cardiomyocytes under hypoxia, and the expressions of apoptotic molecules, such as Bax, cytochrome C, and caspase 3, and the number of apoptotic cells were also decreased by exogenous miR-132 treatment. These results suggest the potential of miR-132 as an effective therapeutic agent against IR damage to heart by preventing Ca(2+) overload during hypoxic condition and warrant further studies to validate its anti-apoptotic effect in vivo. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 931~937 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Na(+)-Ca(2+) exchanger targeting miR-132 prevents apoptosis of cardiomyocytes under hypoxic condition by suppressing Ca(2+) overload | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Soonchang Hong | - |
dc.contributor.googleauthor | Jiyun Lee | - |
dc.contributor.googleauthor | Hyang-Hee Seo | - |
dc.contributor.googleauthor | Chang Yeon Lee | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.contributor.googleauthor | Sung-Man Kim | - |
dc.contributor.googleauthor | Seahyoung Lee | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Eunhyun Choi | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.03.129 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01921 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A03208 | - |
dc.contributor.localId | A04412 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X15005951 | - |
dc.subject.keyword | NCX | - |
dc.subject.keyword | Ca2þ overload | - |
dc.subject.keyword | Hypoxia | - |
dc.subject.keyword | miR-132 | - |
dc.subject.keyword | Cardiomyocyte | - |
dc.subject.keyword | Apoptosis | - |
dc.contributor.alternativeName | Seo, Hyang Hee | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Lee, Ji Yun | - |
dc.contributor.alternativeName | Hong, Soon Chang | - |
dc.contributor.affiliatedAuthor | Seo, Hyang Hee | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Lee, Ji Yun | - |
dc.contributor.affiliatedAuthor | Hong, Soon Chang | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 460 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 931 | - |
dc.citation.endPage | 937 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.460(4) : 931-937, 2015 | - |
dc.identifier.rimsid | 30619 | - |
dc.type.rims | ART | - |
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