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Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

Authors
 Lim S.M.  ;  Jung M.  ;  Shin S.J.  ;  Baek S.J.  ;  Hur H.  ;  Min B.S.  ;  Baik S.H.  ;  Kim N.K.  ;  Ahn J.-B. 
Citation
 ONCOLOGY, Vol.88(4) : 195-200, 2015 
Journal Title
 ONCOLOGY 
ISSN
 0030-2414 
Issue Date
2015
MeSH
Adenocarcinoma/diagnosis* ; Adenocarcinoma/mortality ; Adult ; Aged ; Colorectal Neoplasms/diagnosis* ; Colorectal Neoplasms/mortality ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Organ Transplantation* ; Prognosis ; Survival Rate ; Transplant Recipients ; Young Adult
Keywords
Colorectal cancer ; Organ transplantation ; Survival
Abstract
BACKGROUND: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. OBJECTIVE: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. METHODS: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. RESULTS: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). CONCLUSION: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.
Full Text
http://www.karger.com/?DOI=10.1159/000369254
DOI
10.1159/000369254
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baek, Se Jin(백세진)
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Lim, Sun Min(임선민)
Jung, Min Kyu(정민규) ORCID logo https://orcid.org/0000-0001-8281-3387
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141389
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