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Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

 Lim S.M.  ;  Jung M.  ;  Shin S.J.  ;  Baek S.J.  ;  Hur H.  ;  Min B.S.  ;  Baik S.H.  ;  Kim N.K.  ;  Ahn J.-B. 
 Oncology, Vol.88(4) : 195-200, 2015 
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BACKGROUND: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. OBJECTIVE: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. METHODS: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. RESULTS: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). CONCLUSION: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김남규(Kim, Nam Kyu)
민병소(Min, Byung Soh)
백세진(Baek, Se Jin)
백승혁(Baik, Seung Hyuk)
신상준(Shin, Sang Joon)
안중배(Ahn, Joong Bae)
임선민(Lim, Sun Min)
정민규(Jung, Min Kyu)
허혁(Hur, Hyuk)
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