0 237

Cited 14 times in

HbA1c for diagnosis and prognosis of gestational diabetes mellitus

Authors
 Soon Sung Kwon  ;  Ja-Young Kwon  ;  Yong-Won Park  ;  Young-Han Kim  ;  Jong-Baeck Lim 
Citation
 DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.110(1) : 38-43, 2015 
Journal Title
 DIABETES RESEARCH AND CLINICAL PRACTICE 
ISSN
 0168-8227 
Issue Date
2015
MeSH
Adult ; Biomarkers/blood ; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes, Gestational/blood ; Diabetes, Gestational/diagnosis* ; Female ; Glucose Tolerance Test ; Glycated Hemoglobin A/analysis* ; Humans ; Postpartum Period/blood ; Pregnancy ; Prognosis ; Retrospective Studies ; Risk Factors
Keywords
Gestational diabetes mellitus ; HbA1c ; Oral glucose tolerance test ; Postpartum diabetes mellitus
Abstract
AIMS: HbA1c is a widely used marker in diagnosing type 2 diabetes mellitus (DM), but its clinical utility in diagnosing gestational diabetes mellitus (GDM) is not established. Here, we evaluated the clinical usefulness of HbA1c in diagnosing GDM and predicting the risk of future type 2 DM development among GDM patients. METHODS: This retrospective, cross-sectional study included 321 subjects who underwent 100-g oral glucose tolerance tests (OGTT) during pregnancy. HbA1c and other variables were analyzed to evaluate their diagnostic performance for GDM. To evaluate the clinical usefulness of HbA1c in predicting future type 2 DM development, we classified GDM subjects who had more than 3 months of follow-up data into two subgroups: those who developed postpartum type 2 DM (PDM) and those who did not. RESULTS: HbA1c was significantly higher in the GDM group than in the normal control group. With the 100-g OGTT as reference, HbA1c showed 91.3% sensitivity and 62% specificity at a cut-off value of 5.05% (32mmol/mol) for GDM diagnosis. At a cut-off value of 5.25% (34mmol/mol), sensitivity was 73.6% and specificity was 77.2%. HbA1c levels during pregnancy were higher in those with PDM than in those without PDM (5.91 [41mmol/mol] vs. 5.44% [36mmol/mol], p<0.001). The prognostic value of HbA1c for PDM was evaluated by ROC curve analysis, with sensitivity of 78.6% and specificity of 72.5% at a cut-off value of 5.55% (37mmol/mol). CONCLUSIONS: HbA1c showed high sensitivity with relatively low specificity for diagnosis of GDM in pregnant women and was a potential predictor of PDM. HbA1c may be able to be used as a simple and less invasive alternative screening test for OGTT in GDM patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S016882271500340X
DOI
10.1016/j.diabres.2015.07.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141362
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse