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Expression of nephrin in the human placenta and fetal membranes

Authors
 Bo Hyon Yun  ;  Seung Mi Lee  ;  Hee Young Cho  ;  Ji Young Kim  ;  Ga Hyun Son  ;  Young Han Kim  ;  Yong Won Park  ;  Beom Jin Lim  ;  Ja Young Kwon 
Citation
 MOLECULAR MEDICINE REPORTS, Vol.12(4) : 5116-5120, 2015 
Journal Title
 MOLECULAR MEDICINE REPORTS 
ISSN
 1791-2997 
Issue Date
2015
MeSH
Adult ; Extraembryonic Membranes/metabolism* ; Female ; Gene Expression* ; Humans ; Membrane Proteins/genetics* ; Membrane Proteins/metabolism ; Placenta/metabolism* ; Pregnancy ; Protein Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Abstract
Nephrin is the signature molecule in the podocyte of the glomerulus that forms the renal slit diaphragm, the main functional unit of the glomerulus. The present study focused on the expression of nephrin in the human placenta, which may also have a role in filtration and the maintenance of homeostasis in the kidneys. A total of nine placentas from normal healthy pregnant females at full term were investigated. Reverse transcription-quantitative polymerase chain reaction, western blotting and immunofluorescence were performed. The expression of nephrin mRNA was relatively increased in the chorion compared with that in the villi and the amnion. The nephrin gene was detected in the villous cytotrophoblast cells and the endothelium of the intravillous vessels. It was also present in the chorionic and amniotic membranous lining, with its distribution being particularly dense in the amniocytes. The identification of nephrin in the human placenta, particularly at the maternal‑fetal interface, provides a novel insight into the molecular basis of the selective permeability of the placental barrier, which requires further elucidation.
Full Text
http://www.spandidos-publications.com/mmr/12/4/5116
DOI
10.3892/mmr.2015.4044
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Cho, Hee Young(조희영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141360
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