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Expression of nephrin in the human placenta and fetal membranes

 Bo Hyon Yun  ;  Seung Mi Lee  ;  Hee Young Cho  ;  Ji Young Kim  ;  Ga Hyun Son  ;  Young Han Kim  ;  Yong Won Park  ;  Beom Jin Lim  ;  Ja Young Kwon 
 Molecular Medicine Reports, Vol.12(4) : 5116-5120, 2015 
Journal Title
 Molecular Medicine Reports 
Issue Date
Nephrin is the signature molecule in the podocyte of the glomerulus that forms the renal slit diaphragm, the main functional unit of the glomerulus. The present study focused on the expression of nephrin in the human placenta, which may also have a role in filtration and the maintenance of homeostasis in the kidneys. A total of nine placentas from normal healthy pregnant females at full term were investigated. Reverse transcription-quantitative polymerase chain reaction, western blotting and immunofluorescence were performed. The expression of nephrin mRNA was relatively increased in the chorion compared with that in the villi and the amnion. The nephrin gene was detected in the villous cytotrophoblast cells and the endothelium of the intravillous vessels. It was also present in the chorionic and amniotic membranous lining, with its distribution being particularly dense in the amniocytes. The identification of nephrin in the human placenta, particularly at the maternal‑fetal interface, provides a novel insight into the molecular basis of the selective permeability of the placental barrier, which requires further elucidation.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
권자영(Kwon, Ja Young) ; 김영한(Kim, Young Han) ; 박용원(Park, Yong Won) ; 윤보현(Yun, Bo Hyon) ; 임범진(Lim, Beom Jin) ; 조희영(Cho, Hee Young)
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