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Abnormal brain activity in social reward learning in children with autism spectrum disorder: an fMRI study

Authors
 Uk-Su Choi  ;  Sun-Young Kim  ;  Hyeon Jeong Sim  ;  Seo-Young Lee  ;  Sung-Yeon Park  ;  Joon-Sup Jeong  ;  Kyeong In Seol  ;  Hyo-Woon Yoon  ;  Kyungun Jhung  ;  Jee-In Park  ;  Keun-Ah Cheon 
Citation
 Yonsei Medical Journal, Vol.56(3) : 705-711, 2015 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2015
Abstract
PURPOSE: We aimed to determine whether Autism Spectrum Disorder (ASD) would show neural abnormality of the social reward system using functional MRI (fMRI). MATERIALS AND METHODS: 27 ASDs and 12 typically developing controls (TDCs) participated in this study. The social reward task was developed, and all participants performed the task during fMRI scanning. RESULTS: ASDs and TDCs with a social reward learning effect were selected on the basis of behavior data. We found significant differences in brain activation between the ASDs and TDCs showing a social reward learning effect. Compared with the TDCs, the ASDs showed reduced activity in the right dorsolateral prefrontal cortex, right orbitofrontal cortex, right parietal lobe, and occipital lobe; however, they showed increased activity in the right parahippocampal gyrus and superior temporal gyrus. CONCLUSION: These findings suggest that there might be neural abnormality of the social reward learning system of ASDs. Although this study has several potential limitations, it presents novel findings in the different neural mechanisms of social reward learning in children with ASD and a possible useful biomarker of high-functioning ASDs.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141348
DOI
10.3349/ymj.2015.56.3.705
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김선영(Kim, Sun Young) ; 박지인(Park, Jee In) ; 천근아(Cheon, Keun Ah)
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