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Cerebral Microbleeds in Patients with Dementia with Lewy Bodies and Parkinson Disease Dementia

Authors
 S.W. Kim  ;  S.J. Chung  ;  Y.-S. Oh  ;  J.H. Yoon  ;  M.K. Sunwoo  ;  J.Y. Hong  ;  J.-S. Kim  ;  P.H. Lee 
Citation
 AMERICAN JOURNAL OF NEURORADIOLOGY, Vol.36(9) : 1642-1647, 2015 
Journal Title
 AMERICAN JOURNAL OF NEURORADIOLOGY 
ISSN
 0195-6108 
Issue Date
2015
MeSH
Aged ; Amyloid beta-Peptides/analysis ; Cerebral Hemorrhage/epidemiology* ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/pathology* ; Female ; Humans ; Lewy Body Disease/complications* ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Odds Ratio ; Parkinson Disease/complications* ; Prevalence ; Risk Factors
Abstract
BACKGROUND AND PURPOSE: The burden of amyloid β is greater in patients with dementia with Lewy bodies than in those with Parkinson disease dementia, and an increased amyloid β load is closely related to a higher incidence of cerebral microbleeds. Here, we investigated the prevalence and topography of cerebral microbleeds in patients with dementia with Lewy bodies and those with Parkinson disease dementia to examine whether cerebral microbleeds are more prevalent in patients with dementia with Lewy bodies than in those with Parkinson disease dementia. MATERIALS AND METHODS: The study population consisted of 42 patients with dementia with Lewy bodies, 88 patients with Parkinson disease dementia, and 35 controls who underwent brain MR imaging with gradient recalled-echo. Cerebral microbleeds were classified as deep, lobar, or infratentorial. RESULTS: The frequency of cerebral microbleeds was significantly greater in patients with dementia with Lewy bodies (45.2%) than in those with Parkinson disease dementia (26.1%) or in healthy controls (17.1%; P = .017). Lobar cerebral microbleeds were observed more frequently in the dementia with Lewy bodies group (40.5%) than in the Parkinson disease dementia (17%; P = .004) or healthy control (8.6%; P = .001) group, whereas the frequencies of deep and infratentorial cerebral microbleeds did not differ among the 3 groups. Logistic regression analyses revealed that, compared with the healthy control group, the dementia with Lewy bodies group was significantly associated with the presence of lobar cerebral microbleeds after adjusting for age, sex, nonlobar cerebral microbleeds, white matter hyperintensities, and other vascular risk factors (odds ratio, 4.39 [95% CI, 1.27-15.25]). However, compared with the healthy control group, the Parkinson disease dementia group was not significantly associated with lobar cerebral microbleeds. CONCLUSIONS: This study showed that patients with dementia with Lewy bodies had a greater burden of cerebral microbleeds and exhibited a lobar predominance of cerebral microbleeds than did patients with Parkinson disease dementia.
Full Text
http://www.ajnr.org/content/36/9/1642.long
DOI
10.3174/ajnr.A4337
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141241
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