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Hepatic fibrosis assessed using transient elastography independently associated with coronary artery calcification

Authors
 Seng Chan You  ;  Kwang Joon Kim  ;  Seung Up Kim  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang Hyub Han 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.30(10) : 1536-1542, 2015 
Journal Title
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 
ISSN
 0815-9319 
Issue Date
2015
MeSH
Calcinosis* ; Coronary Artery Disease/complications* ; Coronary Disease/complications* ; Elasticity ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Liver/physiopathology ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/etiology* ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/physiopathology ; Retrospective Studies ; Sex Factors
Keywords
coronary artery calcification ; fibroscan ; healthy subjects ; liver fibrosis ; liver stiffness ; nonalcoholic fatty liver disease ; nonalcoholic steatohepatitis ; transient elastography
Abstract
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) has a close relationship with coronary atherosclerosis. We investigated the association between coronary atherosclerosis and liver fibrosis, represented as coronary artery calcification (CAC) score, and live stiffness (LS) value assessed using transient elastography (TE), respectively, in patients with NAFLD. METHODS: Between January 2013 and March 2014, a total of 285 asymptomatic subjects without chronic liver and ischemic heart diseases who underwent comprehensive medical health check-up were recruited. NAFLD was defined as controlled attenuation parameter (CAP) ≥ 250 dB/m on TE. RESULTS: The median age of the study population (men 161 and women 124) was 56 (interquartile [IQR], 50-63) years. Of these, 142 (49.8%) subjects had NAFLD. Among subjects with NAFLD, CAC score was independently correlated with the male gender (β = 0.230; P = 0.010), elevated erythrocyte sedimentation rate (β = 0.220; P = 0.019), reduced estimated glomerular filtration rate (β=-0.220; P = 0.004), increased left ventricular mass index (β = 0.226; P = 0.027), and higher LS values (β = 0.274; P < 0.001). In addition, alanine aminotransferase level (β = 0.214, P = 0.012) and CAC score (β = 0.311; P = 0.001) are the only independent factors associated with LS values in subjects with NAFLD. CONCLUSIONS: Higher CAC score was independently correlated with LS values in subjects with NAFLD. However, it should be further investigated whether TE can be incorporated into a screening tool to identify the high-risk population for coronary artery disease.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jgh.12992/abstract
DOI
10.1111/jgh.12992
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
You, Seng Chan(유승찬)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141204
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