Cited 5 times in
Exovascular application of epigallocatechin-3-O-gallate-releasing electrospun poly(L-lactide glycolic acid) fiber sheets to reduce intimal hyperplasia in injured abdominal aorta
DC Field | Value | Language |
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dc.contributor.author | 이미희 | - |
dc.contributor.author | 구민아 | - |
dc.contributor.author | 권병주 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 선경미 | - |
dc.date.accessioned | 2016-02-04T11:46:45Z | - |
dc.date.available | 2016-02-04T11:46:45Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141183 | - |
dc.description.abstract | Intimal hyperplasia is an excessive ingrowth of tissue resulting in chronic structural lesions commonly found at sites of atherosclerotic lesions, arterial angioplasty, vascular graft anastomoses, and other vascular abnormalities. Epigallocatechin-3-O-gallate (EGCG) was shown to elicit antioxidant, anti-proliferative, and anti-thrombogenic effects. In this study, we used an electrospinning technique to synthesize EGCG-eluting biodegradable poly(L-lactide glycolic acid) (PLGA) fiber sheets for local delivery of EGCG and investigated the effect of their exovascular application on intimal hyperplasia following balloon-induced abdominal aorta injury in a rabbit experimental model. The morphology of the composite sheets was characterized using scanning electron microscopy and Fourier transform-infrared spectroscopy. EGCG was loaded and dispersed into the PLGA-based electrospun fibers. The EGCG-loaded PLGA sheets exhibited sustained EGCG release following the initial 24 h of burst release in phosphate-buffered saline. In vivo studies demonstrated significant inhibition of intimal hyperplasia following the application of the EGCG-eluting electrospun PLGA fiber sheets, compared with vehicle PLGA controls. In conclusion, our results show that exovascular application of EGCG-eluting PLGA electrospun fiber sheets may provide a useful system for the effective local delivery of drugs for the prevention of intimal hyperplasia. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Exovascular application of epigallocatechin-3-O-gallate-releasing electrospun poly(L-lactide glycolic acid) fiber sheets to reduce intimal hyperplasia in injured abdominal aorta | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | Mi Hee Lee | - |
dc.contributor.googleauthor | Byeong-ju Kwon | - |
dc.contributor.googleauthor | Min-Ah Koo | - |
dc.contributor.googleauthor | Eui Hwa Jang | - |
dc.contributor.googleauthor | Gyeung Mi Seon | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.identifier.doi | 10.1088/1748-6041/10/5/055010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00190 | - |
dc.contributor.localId | A00218 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01932 | - |
dc.contributor.localId | A02777 | - |
dc.relation.journalcode | J00318 | - |
dc.identifier.eissn | 1748-605X | - |
dc.identifier.url | http://stacks.iop.org/1748-6041/10/055010 | - |
dc.subject.keyword | epigallocatechin-3-O-gallate | - |
dc.subject.keyword | local drug delivery | - |
dc.subject.keyword | electrospun poly(l-lactide glycolic acid) fiber sheets | - |
dc.subject.keyword | intimal hyperplasia | - |
dc.subject.keyword | balloon injury | - |
dc.contributor.alternativeName | Lee, Mi Hee | - |
dc.contributor.alternativeName | Koo, Min Ah | - |
dc.contributor.alternativeName | Kwon, Byeong Ju | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Seon, Gyeung Mi | - |
dc.contributor.affiliatedAuthor | Koo, Min Ah | - |
dc.contributor.affiliatedAuthor | Kwon, Byeong Ju | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Seon, Gyeung Mi | - |
dc.contributor.affiliatedAuthor | Lee, Mi Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 055010 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, Vol.10(5) : 055010, 2015 | - |
dc.identifier.rimsid | 29350 | - |
dc.type.rims | ART | - |
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