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Effect of eicosapentaenoic acid on cholesterol gallstone formation in C57BL/6J mice

Authors
 Soo‑Min Cho  ;  Jin‑A Park  ;  Na‑Hyun Kim  ;  Dong‑Soon Kim  ;  Dan Zhang  ;  Hee Yi  ;  Hee‑Jung Cho  ;  Ja Kyung Kim  ;  Dong Ki Lee  ;  Jin‑Suk Kim  ;  Ho‑Chul Shin 
Citation
 Molecular Medicine Reports, Vol.11(1) : 362-366, 2015 
Journal Title
 Molecular Medicine Reports 
ISSN
 1791-2997 
Issue Date
2015
Abstract
The present study investigated the preventive effect of ω-3 fatty acids against cholesterol gallstone (CG) formation. CG formation was induced in C57BL/6J mice using a lithogenic diet (LD). The mice were divided into four treatment groups: i) LD, ii) LD plus eicosapentaenoic acid (EPA), iii) LD plus docosahexaenoic acid (DHA) and iv) LD plus EPA plus DHA. Subsequent to feeding the mice the LD for four weeks, EPA and/or DHA (70 mg/kg/day) were orally administered for eight weeks. The mice in the EPA treatment groups exhibited significantly less gallstone formation than those in the LD group. By contrast, DHA treatment only slightly suppressed gallstone formation. The expression of mucin 2, 5AC, 5B and 6 was significantly decreased in the gallbladders of mice in the EPA groups (70-90%) and the LD plus DHA group (30-50%), compared with that in the mice in the LD group. In addition, the mRNA expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase was significantly decreased in the livers of mice in the EPA treatment group compared with that in the livers of mice in the LD group. In conclusion, EPA was found to have a dominant anti-lithogenic effect in C57BL/6J mice.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141108
DOI
10.3892/mmr.2014.2687
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김자경(Kim, Ja Kyung) ; 이동기(Lee, Dong Ki)
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Full Text
http://www.spandidos-publications.com/mmr/11/1/362/abstract
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