Cited 0 times in

39 0

Effect of eicosapentaenoic acid on cholesterol gallstone formation in C57BL/6J mice

Authors
 Soo‑Min Cho ; Jin‑A Park ; Ho‑Chul Shin ; Jin‑Suk Kim ; Dong Ki Lee ; Ja Kyung Kim ; Hee‑Jung Cho ; Hee Yi ; Dan Zhang ; Dong‑Soon Kim ; Na‑Hyun Kim 
Citation
 Molecular Medicine Reports, Vol.11(1) : 362~366, 2015 
Journal Title
 Molecular Medicine Reports 
ISSN
 1791-2997 
Issue Date
2015
Abstract
The present study investigated the preventive effect of ω-3 fatty acids against cholesterol gallstone (CG) formation. CG formation was induced in C57BL/6J mice using a lithogenic diet (LD). The mice were divided into four treatment groups: i) LD, ii) LD plus eicosapentaenoic acid (EPA), iii) LD plus docosahexaenoic acid (DHA) and iv) LD plus EPA plus DHA. Subsequent to feeding the mice the LD for four weeks, EPA and/or DHA (70 mg/kg/day) were orally administered for eight weeks. The mice in the EPA treatment groups exhibited significantly less gallstone formation than those in the LD group. By contrast, DHA treatment only slightly suppressed gallstone formation. The expression of mucin 2, 5AC, 5B and 6 was significantly decreased in the gallbladders of mice in the EPA groups (70-90%) and the LD plus DHA group (30-50%), compared with that in the mice in the LD group. In addition, the mRNA expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase was significantly decreased in the livers of mice in the EPA treatment group compared with that in the livers of mice in the LD group. In conclusion, EPA was found to have a dominant anti-lithogenic effect in C57BL/6J mice.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141108
DOI
10.3892/mmr.2014.2687
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.spandidos-publications.com/mmr/11/1/362/abstract
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse