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Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Authors
 Mi Jung Lee  ;  Sul A Lee  ;  Bo Young Nam  ;  Sungha Park  ;  Sang-Hak Lee  ;  Han Jak Ryu  ;  Young Eun Kwon  ;  Yung Ly Kim  ;  Kyoung Sook Park  ;  Hyung Jung Oh  ;  Jung Tak Park  ;  Seung Hyeok Han  ;  Dong-Ryeol Ryu  ;  Shin-Wook Kang  ;  Tae-Hyun Yoo 
Citation
 ATHEROSCLEROSIS, Vol.242(2) : 476-482, 2015 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2015
MeSH
Adult ; Aged ; Anthropometry ; Arm/physiology ; Body Mass Index ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnosis* ; Carotid Intima-Media Thickness ; Case-Control Studies ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibronectins/blood* ; Humans ; Inflammation ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Peritoneal Dialysis* ; Sarcopenia/blood ; Sarcopenia/diagnosis*
Keywords
Carotid atherosclerosis ; Irisin ; Myokine ; Peritoneal dialysis ; Sarcopenia
Abstract
OBJECTIVE: In end-stage renal disease, deleterious effect of sarcopenia on cardiovascular disease has been explained mainly by chronic inflammation. However, evidence emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we sought to investigate the effect of irisin, a recently introduced myokine, on the association between sarcopenia and cardiovascular disease in peritoneal dialysis (PD) patients. METHODS: Serum irisin concentrations were assessed by enzyme-linked immunosorbent assay in 102 prevalent PD patients and 35 age- and sex-matched controls. To determine sarcopenia and cardiovascular disease, anthropometric indices including mid-arm muscle circumference (MAMC) and carotid intima-media thickness (cIMT) were measured. RESULTS: Serum irisin concentrations were significantly lower in PD patients than in controls (184.2 ± 88.0 vs. 457.2 ± 105.5 ng/mL, P < 0.001). In PD patients, univariate linear regression analysis showed that serum irisin was positively correlated with MAMC and thigh circumference, but negatively correlated with residual renal function and cIMT. Multivariate analysis revealed that MAMC (per 1 cm increase, B = 8.78, 95% confidence interval [CI] = 0.77-16.79, P = 0.03) had an independent association with serum irisin. In addition, serum irisin was a significant independent predictor for carotid atherosclerosis even after adjustment for high-sensitivity C-reactive protein in PD patients (per 1 g/mL increase, odds ratio = 0.990, 95% CI = 0.982-0.997, P = 0.007). CONCLUSION: This study demonstrated that serum irisin was significantly associated with sarcopenia and carotid atherosclerosis in PD patients. Additional studies to provide a confirmation and examine possible mechanisms are warranted.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915015300654
DOI
10.1016/j.atherosclerosis.2015.08.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kwon, Young Eun(권영은)
Kim, Yung Ly(김영리)
Ryu, Dong Ryeol(류동열)
Ryu, Han Jak(류한작)
Park, Kyoung Sook(박경숙)
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Lee, Sul A(이슬아)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141078
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