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Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

 Mi Jung Lee  ;  Sul A Lee  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Dong-Ryeol Ryu  ;  Seung Hyeok Han  ;  Jung Tak Park  ;  Hyung Jung Oh  ;  Kyoung Sook Park  ;  Yung Ly Kim  ;  Young Eun Kwon  ;  Han Jak Ryu  ;  Sang-Hak Lee  ;  Sungha Park  ;  Bo Young Nam 
 Atherosclerosis, Vol.242(2) : 476-482, 2015 
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OBJECTIVE: In end-stage renal disease, deleterious effect of sarcopenia on cardiovascular disease has been explained mainly by chronic inflammation. However, evidence emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we sought to investigate the effect of irisin, a recently introduced myokine, on the association between sarcopenia and cardiovascular disease in peritoneal dialysis (PD) patients. METHODS: Serum irisin concentrations were assessed by enzyme-linked immunosorbent assay in 102 prevalent PD patients and 35 age- and sex-matched controls. To determine sarcopenia and cardiovascular disease, anthropometric indices including mid-arm muscle circumference (MAMC) and carotid intima-media thickness (cIMT) were measured. RESULTS: Serum irisin concentrations were significantly lower in PD patients than in controls (184.2 ± 88.0 vs. 457.2 ± 105.5 ng/mL, P < 0.001). In PD patients, univariate linear regression analysis showed that serum irisin was positively correlated with MAMC and thigh circumference, but negatively correlated with residual renal function and cIMT. Multivariate analysis revealed that MAMC (per 1 cm increase, B = 8.78, 95% confidence interval [CI] = 0.77-16.79, P = 0.03) had an independent association with serum irisin. In addition, serum irisin was a significant independent predictor for carotid atherosclerosis even after adjustment for high-sensitivity C-reactive protein in PD patients (per 1 g/mL increase, odds ratio = 0.990, 95% CI = 0.982-0.997, P = 0.007). CONCLUSION: This study demonstrated that serum irisin was significantly associated with sarcopenia and carotid atherosclerosis in PD patients. Additional studies to provide a confirmation and examine possible mechanisms are warranted.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ; 권영은(Kwon, Young Eun) ; 김영리(Kim, Yung Ly) ; 류동열(Ryu, Dong Ryeol) ; 류한작(Ryu, Han Jak) ; 박경숙(Park, Kyoung Sook) ; 박성하(Park, Sung Ha) ; 박정탁(Park, Jung Tak) ; 오형중(Oh, Hyung Jung) ; 유태현(Yoo, Tae Hyun) ; 이미정(Lee, Mi Jung) ; 이상학(Lee, Snag Hak) ; 이슬아(Lee, Sul A) ; 한승혁(Han, Seung Hyeok)
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