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담도유두종 환자에서 광역학치료 후 간용적 보존 수술 1예

Other Titles
 Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report 
Authors
 정진옥  ;  임진홍  ;  박준성  ;  박승우  ;  김현기  ;  김경식 
Citation
 Korean Journal of Gastroenterology, Vol.66(1) : 55-58, 2015 
Journal Title
 Korean Journal of Gastroenterology 
ISSN
 1598-9992 
Issue Date
2015
MeSH
Antineoplastic Agents/therapeutic use ; Bile Duct Neoplasms/diagnosis* ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/surgery ; Bile Ducts, Intrahepatic/pathology ; Embolization, Therapeutic ; Gamma Rays ; Hepatectomy ; Hepatic Duct, Common/pathology ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Papilloma/diagnosis* ; Papilloma/drug therapy ; Papilloma/surgery ; Photochemotherapy ; Tegafur/therapeutic use ; Uracil/therapeutic use
Keywords
Papilloma, intraducal ; Hepatectomy ; Photochemotherapy
Abstract
Biliary papillomatosis is rare, and its pathogenic mechanisms are not yet clear. Because of its high risk for malignancy transformation, surgical resection is regarded as a standard treatment. Photodynamic therapy (PDT) has been used by the intravenous administration of hematoporphyrin derivative followed by laser exposure. A photochemical process causes disturbance of the microvascular structure and degradation of membrane. Cholangitis is a major complication after PDT. A healthy 56-year-old man was diagnosed with biliary papillomatosis involving the common hepatic duct, both proximal intrahepatic bile ducts (IHD), and the right posterior IHD. After biliary decompression by endoscopic nasobiliary drainage, PDT was performed to avoid extensive liver resection and recurrence using endoscopic retrograde cholangiographic guidance. After portal vein embolization, the patient underwent extended right hemihepatectomy. Following administration of chemoradiation therapy with tegafur-uracil and 45 Gy due to local recurrence at postoperative 13 months, there was no local recurrence or distant metastases. This is the first case report on PDT for biliary papillomatosis in Korea. Preoperative PDT is beneficial for reducing the lesion in diffuse or multifocal biliary papillomatosis and may lead to curative and volume reserving surgery. Thus, PDT could improve the quality of life and prolong life expectation for biliary papillomatosis patients.
Files in This Item:
T201503226.pdf Download
DOI
10.4166/kjg.2015.66.1.55
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Lim, Jin Hong(임진홍)
Cheong, Chin Ock(정진옥)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141013
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