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Echocardiographic evaluation of the effects of dexmedetomidine on cardiac function during total intravenous anaesthesia

Authors
 S. H. Lee  ;  Y. S. Choi  ;  G. R. Hong  ;  Y. J. Oh 
Citation
 Anaesthesia, Vol.70(9) : 1052-1059, 2015 
Journal Title
 Anaesthesia 
ISSN
 0003-2409 
Issue Date
2015
Abstract
The purpose of this study was to investigate the effects of dexmedetomidine on biventricular systolic and diastolic function using transoesophageal echocardiography. Cardiac function was assessed in 30 healthy patients who received total intravenous anaesthesia with propofol and remifentanil. The echocardiographic examinations were performed just before and 20, 40 and 60 min after dexmedetomidine or saline administration. Patients who received dexmedetomidine, compared with saline after 20 min, had a lower mean (SD) heart rate (56.7 (5.2) vs. 67.1 (7.1) beats.min(-1) ), higher systolic blood pressure (125.7 (18.9) vs. 109 (7.9) mmHg), and lower cardiac output (2.9 (0.5) vs. 3.7 (1.0) l.min(-1) ), respectively (all p < 0.05). In contrast, no changes were observed in biventricular systolic and diastolic indices in either group, and there were no inter-group differences at any time point. Dexmedetomidine, as an adjuvant to total intravenous anaesthesia, does not impair biventricular systolic and diastolic function in healthy patients, but decreases cardiac output by reducing heart rate.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141005
DOI
10.1111/anae.13084
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
오영준(Oh, Young Jun) ; 이수현(Lee, Su Hyun) ; 최용선(Choi, Yong Seon) ; 홍그루(Hong, Geu Ru)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/anae.13084/abstract
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