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Echocardiographic evaluation of the effects of dexmedetomidine on cardiac function during total intravenous anaesthesia

 S. H. Lee  ;  Y. S. Choi  ;  G. R. Hong  ;  Y. J. Oh 
 ANAESTHESIA, Vol.70(9) : 1052-1059, 2015 
Journal Title
Issue Date
Adult ; Anesthesia, Intravenous* ; Cardiac Output/drug effects ; Dexmedetomidine/pharmacology* ; Echocardiography, Transesophageal/methods* ; Echocardiography, Transesophageal/statistics & numerical data ; Female ; Heart Rate/drug effects ; Humans ; Hypnotics and Sedatives/pharmacology* ; Male
The purpose of this study was to investigate the effects of dexmedetomidine on biventricular systolic and diastolic function using transoesophageal echocardiography. Cardiac function was assessed in 30 healthy patients who received total intravenous anaesthesia with propofol and remifentanil. The echocardiographic examinations were performed just before and 20, 40 and 60 min after dexmedetomidine or saline administration. Patients who received dexmedetomidine, compared with saline after 20 min, had a lower mean (SD) heart rate (56.7 (5.2) vs. 67.1 (7.1) beats.min(-1) ), higher systolic blood pressure (125.7 (18.9) vs. 109 (7.9) mmHg), and lower cardiac output (2.9 (0.5) vs. 3.7 (1.0) l.min(-1) ), respectively (all p < 0.05). In contrast, no changes were observed in biventricular systolic and diastolic indices in either group, and there were no inter-group differences at any time point. Dexmedetomidine, as an adjuvant to total intravenous anaesthesia, does not impair biventricular systolic and diastolic function in healthy patients, but decreases cardiac output by reducing heart rate.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Su Hyun(이수현)
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
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