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Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study

Authors
 Park K.S. ; Ryu G.W. ; Park J.T. ; Kang S.-W. ; Kim N.-H. ; Yang C.W. ; Kim Y.S. ; Kim Y.-L. ; Yoo T.-H. ; Han S.H. ; Lee M.J. ; Ryu H.J. ; Kim Y.L. ; Kwon Y.E. ; Lee S.A. ; Park S. ; Kim H.W. ; Jhee J.H. 
Citation
 Blood Purification, Vol.40(3) : 209~217, 2015 
Journal Title
 Blood Purification 
ISSN
 0253-5068 
Issue Date
2015
Abstract
BACKGROUND: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. METHODS: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. RESULTS: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). CONCLUSION: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141001
DOI
10.1159/000438819
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.karger.com/Article/FullText/438819
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