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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Authors
 Jimmy Z Liu  ;  Suzanne van Sommeren  ;  Hailiang Huang  ;  Siew C Ng  ;  Rudi Alberts  ;  Atsushi Takahashi  ;  Stephan Ripke  ;  James C Lee  ;  Luke Jostins  ;  Tejas Shah  ;  Shifteh Abedian  ;  Jae Hee Cheon  ;  Judy Cho  ;  Naser E Daryani  ;  Lude Franke  ;  Yuta Fuyuno  ;  Ailsa Hart  ;  Ramesh C Juyal  ;  Garima Juyal  ;  Won Ho Kim  ;  Andrew P Morris  ;  Hossein Poustchi  ;  William G Newman  ;  Vandana Midha  ;  Timothy R Orchard  ;  Homayon Vahedi  ;  Ajit Sood  ;  Joseph J Y Sung  ;  Reza Malekzadeh  ;  Harm-Jan Westra  ;  Keiko Yamazaki  ;  Suk-Kyun Yang  ;  International Multiple Sclerosis Genetics Consortium  ;  International IBD Genetics Consortium  ;  Jeffrey C Barrett  ;  Andre Franke  ;  Behrooz Z Alizadeh  ;  Miles Parkes  ;  Thelma B K  ;  Mark J Daly  ;  Michiaki Kubo  ;  Carl A Anderson  ;  Rinse K Weersma 
Citation
 Nature Genetics, Vol.47(9) : 979-986, 2015 
Journal Title
 Nature Genetics 
ISSN
 1061-4036 
Issue Date
2015
Abstract
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140996
DOI
10.1038/ng.3359
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김원호(Kim, Won Ho)
천재희(Cheon, Jae Hee)
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Full Text
http://www.nature.com/ng/journal/v47/n9/full/ng.3359.html
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