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A Drosophila Gustatory Receptor Required for Strychnine Sensation

Authors
 Youngseok Lee  ;  Seok Jun Moon  ;  Yijin Wang  ;  Craig Montell 
Citation
 CHEMICAL SENSES, Vol.40(7) : 525-533, 2015 
Journal Title
 CHEMICAL SENSES 
ISSN
 0379-864X 
Issue Date
2015
MeSH
Action Potentials ; Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism* ; Drosophila melanogaster ; Mutation ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism* ; Sensation* ; Strychnine/analysis* ; Strychnine/metabolism*
Keywords
bitter ; chemosensation ; feeding ; fruit fly ; taste
Abstract
Strychnine is a potent, naturally occurring neurotoxin that effectively protects plants from animal pests by deterring feeding behavior. In insects, such as the fruit fly, Drosophila melanogaster, bitter-tasting aversive compounds are detected primarily through a family of gustatory receptors (GRs), which are expressed in gustatory receptor neurons. We previously described multiple GRs that eliminate the behavioral avoidance to all bitter compounds tested, with the exception of strychnine. Here, we report the identity of a strychnine receptor, referred to as GR47a. We generated a mutation in Gr47a and found that it eliminated strychnine repulsion and strychnine-induced action potentials. GR47a was narrowly tuned, as the responses to other avoidance compounds were unaffected in the mutant animals. This analysis supports an emerging model that Drosophila GRs fall broadly into two specificity classes-one class is comprised of core receptors that are broadly required, whereas the other class, which includes GR47a, consists of narrowly tuned receptors that define chemical specificity.
Full Text
http://chemse.oxfordjournals.org/content/40/7/525.long
DOI
10.1093/chemse/bjv038
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140969
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