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Effects of Palonosetron on Perioperative Cardiovascular Complications in Patients Undergoing Noncardiac Surgery With General Anesthesia: A Retrospective Cohort Study

Authors
 JJ Min ; HJ Kim ; Y Jeon ; B-J Park ; DM Hong ; TK Kim ; H-J Jung ; K Kwon ; BG Kim ; S-Y Jung 
Citation
 Clinical Pharmacology & Therapeutics, Vol.98(1) : 96~106, 2015 
Journal Title
 Clinical Pharmacology & Therapeutics 
ISSN
 0009-9236 
Issue Date
2015
Abstract
We retrospectively investigated whether palonosetron administered during the induction of general anesthesia is associated with an increased risk of perioperative cardiovascular complications in a single tertiary center cohort consisting of 4,517 palonosetron-exposed patients and 4,517 propensity score-matched patients without palonosetron exposure. The primary endpoint was a composite of perioperative cardiovascular complications, including intraoperative cardiac arrhythmia, intraoperative cardiac death, and myocardial injury within the first postoperative week, and there was no significant difference between the groups (odds ratio [OR] = 1.04; 95% confidence interval [CI] = 0.92-1.19). As secondary endpoints, intraoperative cardioversion, cardiac compression, use of cardiovascular drugs, postoperative hospital stay, and in-hospital mortality showed no differences between the groups. However, the palonosetron group showed decreased intraoperative hypotension (OR = 0.88; 95% CI = 0.79-0.97) and length of postoperative intensive care unit (ICU) stay (4.26 ± 9.86 vs. 6.14 ± 16.75; P = 0.026). Palonosetron did not increase the rate of perioperative cardiovascular complications, and can therefore be used safely during anesthetic induction.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140926
DOI
10.1002/cpt.121
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/cpt.121/abstract
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