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Evaluating Variations of Bladder Volume Using an Ultrasound Scanner in Rectal Cancer Patients during Chemoradiation: Is Protocol-Based Full Bladder Maintenance Using a Bladder Scanner Useful to Maintain the Bladder Volume?

Authors
 Hong In Yoon  ;  Yoonsun Chung  ;  Jee Suk Chang  ;  Joo Yong Lee  ;  Soo Jung Park  ;  Woong Sub Koom 
Citation
 PLOS ONE, Vol.10(6) : e0128791, 2015 
Journal Title
 PLOS ONE 
Issue Date
2015
MeSH
Adult ; Aged ; Antineoplastic Agents/therapeutic use* ; Female ; Fluorouracil/therapeutic use ; Gamma Rays/therapeutic use* ; Humans ; Leucovorin/therapeutic use ; Logistic Models ; Male ; Middle Aged ; Prospective Studies ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/pathology ; Rectal Neoplasms/radiotherapy* ; Tomography, X-Ray Computed ; Ultrasonography ; Urinary Bladder/diagnostic imaging* ; Urography/methods
Abstract
PURPOSE: The maintenance of full bladder is important to reduce radiation-induced toxicities and maintain the therapeutic consistency in locally advanced rectal cancer patients who underwent radiotherapy (RT). So, the aim of this study was to evaluate the effectiveness of protocol-based full bladder maintenance by assessing bladder volume variation using an ultrasound bladder scanner to maintain bladder volume. MATERIALS AND METHODS: From March 2011 to May 2011, twenty consecutive rectal cancer patients receiving external beam RT participated in this prospective study. Protocol-based full bladder maintenance consisted of education, training and continuous biofeedback by measuring bladder volume. Bladder volume was measured by bladder scan immediately before simulation CT scan and before each treatment three times weekly during the RT period. The relative bladder volume change was calculated. Intra-patient bladder volume variations were quantified using interquartile range (IQR) of relative bladder volume change in each patient. We compared intra-patient bladder volume variations obtained (n=20) with data from our previous study patients (n=20) performing self-controlled maintenance without protocol. RESULTS: Bladder volumes measured by bladder scan highly correlated with those on simulation CT scan (R=0.87, p<0.001). Patients from this study showed lower median IQR of relative bladder volume change compared to patients of self-controlled maintenance from our previous study, although it was not statistically significant (median 32.56% vs. 42.19%, p=0.058). Upon logistic regression, the IQR of relative bladder volume change was significantly related to protocol-based maintenance [relative risk 1.045, 95% confidence intervals (CI) 1.004-1.087, p=0.033]. Protocol-based maintenance included significantly more patients with an IQR of relative bladder volume change less than 37% than self-controlled maintenance (p=0.025). CONCLUSION: Our findings show that bladder volume could be maintained more consistently during RT by protocol-based management using a bladder scan.
Files in This Item:
T201503070.pdf Download
DOI
10.1371/journal.pone.0128791
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Park, Soo Jung(박수정)
Lee, Joo Yong(이주용) ORCID logo https://orcid.org/0000-0002-3470-1767
Chang, Jee Suk Paul(장지석) ORCID logo https://orcid.org/0000-0001-7685-3382
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140923
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