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Usefulness of the controlled attenuation parameter for detecting liver steatosis in health checkup examinees

Authors
 Ja Kyung Kim  ;  Kwan Sik Lee  ;  Jung Ran Choi  ;  Hyun Jung Chung  ;  Da Hyun Jung  ;  Kyung Ah Lee  ;  Jung Il Lee 
Citation
 GUT AND LIVER, Vol.9(3) : 405-410, 2015 
Journal Title
 GUT AND LIVER 
ISSN
 1976-2283 
Issue Date
2015
MeSH
Adult ; Body Mass Index ; Body Weight ; Elasticity Imaging Techniques/methods* ; Fatty Liver/diagnostic imaging* ; Female ; Humans ; Liver/diagnostic imaging* ; Male ; Middle Aged ; Physical Examination/methods* ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Severity of Illness Index
Keywords
Controlled attenuation parameter ; Early diagnosis ; Fatty liver ; Metabolic syndrome ; Ultrasonography
Abstract
BACKGROUND/AIMS: The controlled attenuation parameter (CAP) implemented in FibroScan® is reported to be a noninvasive means of detecting steatosis (>10% steatosis). We aimed to evaluate the usefulness of CAP in detecting steatosis among health checkup examinees and to assess its correlation with ultrasonography (US). METHODS: Consecutive CAP results were retrospectively collected. A total of 280 subjects were included. RESULTS: Fatty liver was detected in 119 subjects (42.5%) by US, whereas it was detected in 160 subjects (57.1%) by the CAP. The numbers of subjects with S0S1S2S3 steatosis according to the CAP value were 120595843, respectively. The mean CAP values were 203.34±28.39 dB/m for S0, 248.83±6.14 dB/m for S1, 274.33±8.53 dB/m for S2, and 322.35±22.20 dB/m for S3. CAP values were correlated with body weight (r=0.404, p<0.001), body mass index (r=0.445, p<0.001), and the fatty liver grade by US (r=0.472, p<0.001). Among the 161 subjects with normal US findings, steatosis was detected in 65 subjects (40.4%) using the CAP. CONCLUSIONS: The CAP seems to be useful for detecting very low-grade hepatic steatosis in health checkup examinees. Its role in predicting subjects with a risk of metabolic derangement needs to be evaluated.
Files in This Item:
T201503020.pdf Download
DOI
10.5009/gnl14202
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Jung, Da Hyun(정다현)
Chung, Hyun Jung(정현정)
Choi, Jung Ran(최정란)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140863
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