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Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects

 Jaewoo Song  ;  Fengju Chen  ;  Marco Campos  ;  Doug Bolgiano  ;  Katie Houck  ;  Lloyd E. Chambless  ;  Kenneth K. Wu  ;  Aaron R. Folsom  ;  David Couper  ;  Eric Boerwinkle  ;  Jing-fei Dong 
 PLOS ONE, Vol.10(8) : e0132626, 2015 
Journal Title
Issue Date
ABO Blood-Group System/blood ; ABO Blood-Group System/genetics* ; African Continental Ancestry Group/genetics ; Atherosclerosis/blood ; Atherosclerosis/genetics* ; European Continental Ancestry Group/genetics ; Factor VIII/analysis* ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Risk Factors ; von Willebrand Factor/analysis*
ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity, and their quantitative relationship in 11,673 participants in the Atherosclerosis Risk in Communities (ARIC) study. VWF, FVIII, and FVIII/VWF levels varied significantly among O, A (A1 and A2), B and AB subjects, and the extent of which varied between Americans of European (EA) and African (AA) descent. We validated a strong influence of ABO blood type on VWF levels (15.2%), but also detected a direct ABO influence on FVIII activity (0.6%) and FVIII/VWF ratio (3.8%) after adjustment for VWF. We determined that FVIII activity changed 0.54% for every 1% change in VWF antigen level. This VWF-FVIII relationship differed between subjects with O and B blood types in EA, AA, and in male, but not female subjects. Variations in FVIII activity were primarily detected at low VWF levels. These new quantitative influences on VWF, FVIII and the FVIII/VWF ratio help understand how ABO genotypes differentially influence VWF, FVIII and their ratio, particularly in racial and gender specific manners.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
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