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혈액투석 환자에서 발생한 카포시육종의 Pazopanib 치료 증례

Other Titles
 Treatment of a Patient with Kaposi’s Sarcoma Arising during Hemodialysis with the Multikinase Inhibitor Pazopanib 
Authors
 천유진 ; 최아란 ; 조재용 ; 임재윤 ; 조장호 ; 김효은 ; 양서연 
Citation
 Korean Journal of Medicine (대한내과학회지), Vol.89(1) : 113~116, 2015 
Journal Title
 Korean Journal of Medicine (대한내과학회지) 
ISSN
 1226-329X 
Issue Date
2015
Abstract
Kaposi’s sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in a patient receiving hemodialysis for 7 years. The patient had a history of chronic renal failure due to glomerulonephritis for 20 years. Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity for human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, a multitarget tyrosine kinase inhibitor, is an effective agent for treatment of advanced soft tissue sarcoma. The patient received pazopanib for 6 months investigate its effects on KS. The skin lesions and painful symptoms showed improvement. Further studies are required to determine the mechanism underlying the anticancer action of pazopanib and the pathogenesis of KS.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140834
DOI
10.3904/kjm.2015.89.1.113
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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