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Effect of isoflurane post-treatment on tPA-exaggerated brain injury in a rat ischemic stroke model

 Eun Jung Kim  ;  So Yeon Kim  ;  Bon Nyeo Koo  ;  Jung Ik Byun  ;  Jin Soo Kim  ;  Jeong Min Kim  ;  Jae Hoon Lee 
 Korean Journal of Anesthesiology, Vol.68(3), 2015 
Journal Title
 Korean Journal of Anesthesiology 
Issue Date
Intracranial hemorrhages ; Ischemic postconditioning ; Isoflurane ; Tissue plasminogen activator
BACKGROUND: Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have required caution when used. In this context, several approaches are required to deal with the shortcomings of such a double-edged drug. Anesthetics are known to protect against ischemic reperfusion injury, and their protective role in ischemic post-conditioning is crucial for reducing ischemia-related injury. The aim of this study was to assess the effect of isoflurane post-treatment on intracranial hemorrhage and cerebral infarction after tPA treatment for transient cerebral ischemia. METHODS: Cerebral ischemia was modeled in male Sprague-Dawley rats (n = 32) by occluding the right middle cerebral artery for 1 h, followed by intravenous tPA administration. Rats were randomly divided into control and isoflurane post-treatment group, and isoflurane post-treatment group was post-treated by administering 1.5% isoflurane for 1 h from the start of reperfusion. Twenty-four h after reperfusion, neurobehavioral changes were assessed. The extent of cerebral infarction and intracranial hemorrhage were also assessed by quantification of infarction volume and cerebral hemoglobin concentration from brain tissue, respectively. RESULTS: Neurobehavioral testing showed better functional outcomes in the isoflurane post-treatment group than the control group. The extent of cerebral infarction and intracranial hemorrhage were both reduced in isoflurane post-treatment group compared to control group. CONCLUSIONS: Isoflurane post-treatment may mitigate infarction volume and intracranial hemorrhage in tPA-exaggerated brain injury. Our findings provide an encouraging novel approach for enhancing clinical outcomes in tPA-exaggerated brain injury.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실)
Yonsei Authors
구본녀(Ku, Bon Nyo) ; 김소연(Kim, So Yeon) ; 김은정(Kim, Eun Jung) ; 김정민(Kim, Jeongmin) ; 이재훈(Lee, Jae Hoon)
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