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Increased large unstained cells value in varicella patients: A valuable parameter to aid rapid diagnosis of varicella infection

 Dongyun Shin  ;  Min Seok Lee  ;  Do Young Kim  ;  Min Geol Lee  ;  Dae Suk Kim 
 Journal of Dermatology, Vol.42(8) : 795-799, 2015 
Journal Title
 Journal of Dermatology 
Issue Date
Varicella is a highly contagious infection caused by varicella zoster virus. Sometimes it is difficult to differentiate between other viral infections such as Kaposi's varicelliform eruption (KVE) and disseminated herpes zoster (HZ). The large unstained cells (LUC) value is a differential count parameter reported by routing hematology analysis. LUC have been studied previously, but never been reported in the context of varicella or in dermatological published work. The aim of this study was to compare the LUC values in varicella patients with that in KVE and disseminated HZ patients. Sixty-nine varicella patients, 30 KVE patients and 11 disseminated HZ patients were included in this retrospective study. All data were analyzed using SPSS version 17.0 or GraphPad Prism version 5.0. The mean percentage of LUC (%LUC) in varicella patients was higher than the upper limit of normal reference range and it was increased compared to %LUC of both KVE (P < 0.0001) and disseminated HZ (P = 0.0051) patients. %LUC of varicella patients significantly decreased with clinical improvements (P = 0.0017). %LUC was significantly increased in varicella patients and corresponded with clinical improvements. Patients with %LUC of 3.55 or more favor the diagnosis of varicella over both KVE and disseminated HZ with 71.01% sensitivity and 84.44% specificity. We suggest that %LUC can assist in making a precise diagnosis of varicella in confusing cases.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
Yonsei Authors
김대석(Kim, Dae Suk)
김도영(Kim, Do Young) ORCID logo https://orcid.org/0000-0002-0194-9854
이민걸(Lee, Min Geol) ORCID logo https://orcid.org/0000-0001-7040-5335
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