1 185

Cited 0 times in

Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis

Authors
 Dae Suk Kim  ;  Jung Hwan Je  ;  Sung Hee Kim  ;  Dongyun Shin  ;  Tae-Gyun Kim  ;  Do Young Kim  ;  Soo Min Kim  ;  Min-Geol Lee 
Citation
 Archives of Dermatological Research, Vol.307(6) : 531-538, 2015 
Journal Title
 Archives of Dermatological Research 
ISSN
 0340-3696 
Issue Date
2015
Abstract
Psoriatic keratinocytes are one of the key components that amplify and maintain chronic inflammation. We hypothesized that lack of proper regulatory functions of keratinocytes can be responsible for chronic inflammation in psoriasis. Programmed death-ligands (PD-L) 1, 2 are expressed on keratinocytes, and expressions by nonlymphoid cells are important for mediating peripheral T cell tolerance. In our study, we investigated whether PD-L1, 2 expressions are altered in keratinocytes of psoriatic epidermis compared to normal epidermis. Epidermis was separated and analyzed for PD-L1, 2 expressions in mRNA and protein levels. Immunohistochemical stainings were done in skin biopsy samples from psoriasis, normal skin, allergic contact dermatitis (ACD), pityriasis rosea (PR) and lichen planus (LP). Expressions of PD-L1, 2 mRNA levels were significantly decreased in psoriatic epidermis compared to normal epidermis. In protein levels, PD-L1 expression was significantly decreased in psoriatic epidermis. However, PD-L2 expression was not detected in both normal and psoriatic epidermis. Immunohistochemical stainings revealed significantly less PD-L1 expression in psoriatic epidermis compared to normal epidermis. Even compared to other cutaneous inflammatory diseases, psoriatic epidermis showed less expression than ACD, PR and LP. PD-L2 expression was minimally detected in normal epidermis and not in psoriatic epidermis, but its expression was increased in ACD, PR and LP. In conclusion, we demonstrated that PD-L1, 2 are decreased in psoriatic epidermis in mRNA and protein levels. In addition, we showed that their expression was significantly lower than other inflammatory skin diseases. We suggest that decreased expression of PD-L1, 2 on psoriatic epidermis can contribute to its chronic unregulated inflammatory characteristics.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140758
DOI
10.1007/s00403-015-1588-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실)
Yonsei Authors
김대석(Kim, Dae Suk) ; 김도영(Kim, Do Young) ; 김태균(Kim, Tae Kyun) ; 이민걸(Lee, Min Geol)
사서에게 알리기
  feedback
Full Text
http://link.springer.com/article/10.1007%2Fs00403-015-1588-5
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse