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Predictors of Urgent Findings on Abdominopelvic CT in Patients with Crohn's Disease Presenting to the Emergency Department

Authors
 Yoon Suk Jung ; Dong Il Park ; Seong Ran Jeon ; Jeong Eun Shin ; Hyun Joo Song ; Soon Man Yoon ; Kyu Chan Huh ; Jae Hak Kim ; Chang Kyun Lee ; Dong Soo Han ; Chang Soo Eun ; Jae Hee Cheon ; Young Ho Kim ; Eun Ran Kim ; Sung Noh Hong 
Citation
 Digestive Diseases and Sciences, Vol.60(4) : 929~935, 2015 
Journal Title
 Digestive Diseases and Sciences 
ISSN
 0163-2116 
Issue Date
2015
Abstract
BACKGROUND: Patients with Crohn's disease (CD) are frequently exposed to diagnostic radiation, mainly as a result of abdominopelvic computed tomography (APCT) examinations. However, there are limited data on the impact of APCT on clinical management in this population. AIM: To investigate clinical predictors of urgent findings on APCT in patients with CD who presented to the emergency department (ED). METHODS: A retrospective study was performed among patients with CD presenting to 11 EDs with a gastrointestinal complaint. The primary outcome, OPAN (obstruction, perforation, abscess, or non-CD-related urgent findings), included new or worsening CD-related urgent findings or non-CD-related urgent findings that required urgent or emergency treatment. Variables with P < 0.1 in univariate analyses were included in a multivariable logistic regression model. RESULTS: Of the 266 APCTs performed, 103 (38.7 %) had OPAN and 113 (42.5 %) required changes in treatment plan. Stricturing or penetrating disease (odds ratio [OR] 2.72, 95 % confidence interval [CI] 1.21-6.13), heart rate >100 beats/min (OR 2.33, 95 % CI 1.10-4.93), leukocyte count >10,000/mm(3) (OR 4.38, 95 % CI 2.10-9.13), and CRP >2.5 mg/dL (OR 3.11, 95 % CI 1.23-7.86) were identified as the independent predictors of OPAN, whereas biologic agent use (OR 0.37; 95 % CI 0.15-0.90) was identified as the negative predictor in patients with CD. CONCLUSIONS: Only 39 % of the APCTs performed in the ED among patients with CD showed urgent findings. Stricturing or penetrating disease, tachycardia, leukocytosis, and high CRP level were predictors of urgent CT findings, while biologic agent use was a negative predictor. To reduce unnecessary radiation exposure, the selection process for CD patients referred for APCT must be improved.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140743
DOI
10.1007/s10620-014-3298-9
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs10620-014-3298-9
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