Cited 93 times in
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes
DC Field | Value | Language |
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dc.contributor.author | 유지환 | - |
dc.date.accessioned | 2016-02-04T11:33:48Z | - |
dc.date.available | 2016-02-04T11:33:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140703 | - |
dc.description.abstract | Genetic studies in Drosophila have demonstrated that generation of microbicidal reactive oxygen species (ROS) through the NADPH dual oxidase (DUOX) is a first line of defense in the gut epithelia. Bacterial uracil acts as DUOX-activating ligand through poorly understood mechanisms. Here, we show that the Hedgehog (Hh) signaling pathway modulates uracil-induced DUOX activation. Uracil-induced Hh signaling is required for intestinal expression of the calcium-dependent cell adhesion molecule Cadherin 99C (Cad99C) and subsequent Cad99C-dependent formation of endosomes. These endosomes play essential roles in uracil-induced ROS production by acting as signaling platforms for PLCβ/PKC/Ca2+-dependent DUOX activation. Animals with impaired Hh signaling exhibit abolished Cad99C-dependent endosome formation and reduced DUOX activity, resulting in high mortality during enteric infection. Importantly, endosome formation, DUOX activation, and normal host survival are restored by genetic reintroduction of Cad99C into enterocytes, demonstrating the important role for Hh signaling in host resistance to enteric infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 191~204 | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacteria/immunology* | - |
dc.subject.MESH | Bacteria/metabolism | - |
dc.subject.MESH | Cadherins/metabolism | - |
dc.subject.MESH | Drosophila/cytology | - |
dc.subject.MESH | Drosophila/immunology | - |
dc.subject.MESH | Drosophila/microbiology* | - |
dc.subject.MESH | Endosomes/metabolism* | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Host-Pathogen Interactions | - |
dc.subject.MESH | Immunity, Mucosal | - |
dc.subject.MESH | Immunologic Factors/metabolism | - |
dc.subject.MESH | Intestinal Mucosa/immunology | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | NADPH Oxidases/metabolism* | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Signal Transduction* | - |
dc.subject.MESH | Uracil/metabolism* | - |
dc.title | Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Research Center for Human Natural Defense System (생체방어연구센터) | - |
dc.contributor.googleauthor | Kyung-Ah Lee | - |
dc.contributor.googleauthor | Boram Kim | - |
dc.contributor.googleauthor | Jinhyuk Bhin | - |
dc.contributor.googleauthor | Do Hun Kim | - |
dc.contributor.googleauthor | Hyejin You | - |
dc.contributor.googleauthor | Eun-Kyoung Kim | - |
dc.contributor.googleauthor | Sung-Hee Kim | - |
dc.contributor.googleauthor | Ji-Hwan Ryu | - |
dc.contributor.googleauthor | Daehee Hwang | - |
dc.contributor.googleauthor | Won-Jae Lee | - |
dc.identifier.doi | 10.1016/j.chom.2014.12.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02522 | - |
dc.relation.journalcode | J00484 | - |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.pmid | 25639794 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1931312814004661 | - |
dc.contributor.alternativeName | Ryu, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Ryu, Ji Hwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 191 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, Vol.17(2) : 191-204, 2015 | - |
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