Cited 14 times in
Vascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic pain
DC Field | Value | Language |
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dc.contributor.author | 김긍년 | - |
dc.contributor.author | 이혜영 | - |
dc.contributor.author | 차려화 | - |
dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2016-02-04T11:33:37Z | - |
dc.date.available | 2016-02-04T11:33:37Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140697 | - |
dc.description.abstract | Previously, we determined that vascular endothelial growth factor (VEGF) improves the survival of neural stem cells (NSCs) transplanted into an ischemic environment and effectively enhances angiogenesis. Here, we applied NSCs expressing VEGF (SV-VEGF-NSCs) to treat neuropathic pain. In this study, our goal was to verify the therapeutic effect of SV-VEGF-NSCs by transplanting the cells in a sciatic nerve injury model. We compared the amount of VEGF secreted from DsRed-NSCs (control) or SV-VEGF-NSCs and observed that SV-VEGF-NSCs have a much higher expression level of VEGF. We next investigated whether transplantation with SV-VEGF-NSCs aids functional recovery and pain reduction. We confirmed that transplantation with SV-VEGF-NSCs enhances functional recovery, pain reduction, and remyelination as well as the number of blood vessels compared with the control groups. Our results show that VEGF aids functional recovery and pain reduction in a sciatic nerve injury model. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 399~404 | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival/physiology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Hyperalgesia/pathology | - |
dc.subject.MESH | Hyperalgesia/physiopathology | - |
dc.subject.MESH | Hyperalgesia/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myelin Sheath/pathology | - |
dc.subject.MESH | Myelin Sheath/physiology | - |
dc.subject.MESH | Neural Stem Cells/metabolism* | - |
dc.subject.MESH | Neuralgia/pathology | - |
dc.subject.MESH | Neuralgia/physiopathology | - |
dc.subject.MESH | Neuralgia/therapy* | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Recovery of Function/physiology | - |
dc.subject.MESH | Sciatic Nerve/injuries | - |
dc.subject.MESH | Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Touch | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/metabolism* | - |
dc.title | Vascular endothelial growth factor-expressing neural stem cell for the treatment of neuropathic pain | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Lee, Hye-Lan | - |
dc.contributor.googleauthor | Oh, Jinsoo | - |
dc.contributor.googleauthor | Yun, Yeomin | - |
dc.contributor.googleauthor | Lee, Hye Yeong | - |
dc.contributor.googleauthor | You, Youngsang | - |
dc.contributor.googleauthor | Che, Lihua | - |
dc.contributor.googleauthor | Lee, Minhyung | - |
dc.contributor.googleauthor | Kim, Keung Nyun | - |
dc.contributor.googleauthor | Ha, Yoon | - |
dc.identifier.doi | 10.1097/WNR.0000000000000359 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A03317 | - |
dc.contributor.localId | A03992 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 25793634 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201505010-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | neural stem cells | - |
dc.subject.keyword | neuropathic pain | - |
dc.subject.keyword | sciatic nerve injury | - |
dc.subject.keyword | vascular endothelial growth factor | - |
dc.contributor.alternativeName | Kim, Keung Nyun | - |
dc.contributor.alternativeName | Lee, Hye Yeong | - |
dc.contributor.alternativeName | Che, Lihua | - |
dc.contributor.alternativeName | Ha, Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Keung Nyun | - |
dc.contributor.affiliatedAuthor | Lee, Hye Yeong | - |
dc.contributor.affiliatedAuthor | Che, Lihua | - |
dc.contributor.affiliatedAuthor | Ha, Yoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 404 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.26(7) : 399-404, 2015 | - |
dc.identifier.rimsid | 30253 | - |
dc.type.rims | ART | - |
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