0 59

Cited 17 times in

Clinical effect of white matter network disruption related to amyloid and small vessel disease

 Hee Jin Kim ; Kiho Im ; Sang Won Seo ; Duk L. Na ; Michael W. Weiner ; Michael Ewers ; Jae Hong Lee ; Sung Tae Kim ; Kyung Han Lee ; Yearn Seong Choe ; Jae Seung Kim ; En-Da Ko ; Geon Ha Kim ; Young Noh ; Byoung Seok Ye ; Hanna Cho ; Na-Yeon Jung ; Yeo Jin Kim ; Changsoo Kim ; Jong-Min Lee ; Hunki Kwon 
 Neurology, Vol.85(1) : 63~70, 2015 
Journal Title
Issue Date
BACKGROUND: We tested our hypothesis that the white matter network might mediate the effect of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition. METHODS: We prospectively recruited 232 patients with cognitive impairment. Amyloid was assessed using Pittsburgh compound B-PET. SVD was quantified as white matter hyperintensity volume and lacune number. The regional white matter network connectivity was measured as regional nodal efficiency by applying graph theoretical analysis to diffusion tensor imaging data. We measured cortical thickness and performed neuropsychological tests. RESULTS: SVD burden was associated with decreased nodal efficiency in the bilateral frontal, lateral temporal, lateral parietal, and occipital regions. Path analyses showed that the frontal nodal efficiency mediated the effect of SVD on the frontal atrophy and frontal-executive dysfunction. The temporoparietal nodal efficiency mediated the effect of SVD on the temporoparietal atrophy and memory dysfunction. However, Pittsburgh compound B retention ratio affected cortical atrophy and cognitive impairment without being mediated by nodal efficiency. CONCLUSIONS: We suggest that a disrupted white matter network mediates the effect of SVD, but not amyloid, on specific patterns of cortical atrophy and/or cognitive impairment. Therefore, our findings provide insight to better understand how amyloid and SVD burden can give rise to brain atrophy or cognitive impairment in specific patterns.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
Yonsei Authors
사서에게 알리기
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.