Cited 43 times in
Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
DC Field | Value | Language |
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dc.contributor.author | 이향규 | - |
dc.date.accessioned | 2016-02-04T11:33:10Z | - |
dc.date.available | 2016-02-04T11:33:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140681 | - |
dc.description.abstract | BACKGROUND: Oligonol is a low molecular weight form of polyphenol polymers derived from lychee fruits. Several studies suggest that Oligonol has an anti-obesity effect. Since obesity is tightly associated with insulin resistance, we investigated a possible remission effect of Oligonol on lipid accumulation and insulin resistance in human hepatic HepG2 cells. METHODS: HepG2 cells were treated with palmitate for 24 h to induce cellular hepatic steatosis and insulin resistance. The cells were then treated with Oligonol at subtoxic concentrations and examined for lipid metabolism, cytokine production, and insulin signaling using quantitative RT-PCR and western blot analysis. RESULTS: Oligonol treatment reversed the palmitate-induced intracellular lipid accumulation, down regulated the expression of lipogenic genes, and up-regulated genes for fatty acid degradation. Oligonol restored insulin sensitivity, as was determined by the phosphorylation states of IRS-1. Oligonol also inhibited STAT3-SOCS3 signaling and increased AMPK phosphorylation in HepG2 cells. CONCLUSION: Oligonol treatment improved palmitate-induced cellular steatosis and insulin resistance in HepG2 cells with concomitant reduction of inflammatory cytokines and decrease in STAT3-SOCS3 and AMPK-mTOR pathways. Oligonol may have beneficial effects in lipid metabolism and insulin resistance in the liver. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 185 | - |
dc.relation.isPartOf | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Catechin/analogs & derivatives* | - |
dc.subject.MESH | Catechin/pharmacology | - |
dc.subject.MESH | Fatty Liver/metabolism* | - |
dc.subject.MESH | Hep G2 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Lipid Metabolism/drug effects* | - |
dc.subject.MESH | Models, Biological* | - |
dc.subject.MESH | Phenols/pharmacology* | - |
dc.title | Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment Systems (임상간호과학과) | - |
dc.contributor.googleauthor | Jae-Yeo Park | - |
dc.contributor.googleauthor | Younghwa Kim | - |
dc.contributor.googleauthor | Jee Ae Im | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.identifier.doi | 10.1186/s12906-015-0709-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03282 | - |
dc.relation.journalcode | J00355 | - |
dc.identifier.eissn | 1472-6882 | - |
dc.identifier.pmid | 26077338 | - |
dc.contributor.alternativeName | Lee, Hyang Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Hyang Kyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 185 | - |
dc.identifier.bibliographicCitation | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.15 : 185, 2015 | - |
dc.identifier.rimsid | 30244 | - |
dc.type.rims | ART | - |
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