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Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model

DC FieldValueLanguage
dc.contributor.author이향규-
dc.date.accessioned2016-02-04T11:33:10Z-
dc.date.available2016-02-04T11:33:10Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140681-
dc.description.abstractBACKGROUND: Oligonol is a low molecular weight form of polyphenol polymers derived from lychee fruits. Several studies suggest that Oligonol has an anti-obesity effect. Since obesity is tightly associated with insulin resistance, we investigated a possible remission effect of Oligonol on lipid accumulation and insulin resistance in human hepatic HepG2 cells. METHODS: HepG2 cells were treated with palmitate for 24 h to induce cellular hepatic steatosis and insulin resistance. The cells were then treated with Oligonol at subtoxic concentrations and examined for lipid metabolism, cytokine production, and insulin signaling using quantitative RT-PCR and western blot analysis. RESULTS: Oligonol treatment reversed the palmitate-induced intracellular lipid accumulation, down regulated the expression of lipogenic genes, and up-regulated genes for fatty acid degradation. Oligonol restored insulin sensitivity, as was determined by the phosphorylation states of IRS-1. Oligonol also inhibited STAT3-SOCS3 signaling and increased AMPK phosphorylation in HepG2 cells. CONCLUSION: Oligonol treatment improved palmitate-induced cellular steatosis and insulin resistance in HepG2 cells with concomitant reduction of inflammatory cytokines and decrease in STAT3-SOCS3 and AMPK-mTOR pathways. Oligonol may have beneficial effects in lipid metabolism and insulin resistance in the liver.-
dc.description.statementOfResponsibilityopen-
dc.format.extent185-
dc.relation.isPartOfBMC COMPLEMENTARY AND ALTERNATIVE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCatechin/analogs & derivatives*-
dc.subject.MESHCatechin/pharmacology-
dc.subject.MESHFatty Liver/metabolism*-
dc.subject.MESHHep G2 Cells-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHLipid Metabolism/drug effects*-
dc.subject.MESHModels, Biological*-
dc.subject.MESHPhenols/pharmacology*-
dc.titleOligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model-
dc.typeArticle-
dc.contributor.collegeCollege of Nursing (간호대학)-
dc.contributor.departmentDept. of Nursing Environment Systems (임상간호과학과)-
dc.contributor.googleauthorJae-Yeo Park-
dc.contributor.googleauthorYounghwa Kim-
dc.contributor.googleauthorJee Ae Im-
dc.contributor.googleauthorHyangkyu Lee-
dc.identifier.doi10.1186/s12906-015-0709-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03282-
dc.relation.journalcodeJ00355-
dc.identifier.eissn1472-6882-
dc.identifier.pmid26077338-
dc.contributor.alternativeNameLee, Hyang Kyu-
dc.contributor.affiliatedAuthorLee, Hyang Kyu-
dc.rights.accessRightsfree-
dc.citation.volume15-
dc.citation.startPage185-
dc.identifier.bibliographicCitationBMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.15 : 185, 2015-
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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