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Recovery from Permanent Hypoparathyroidism After Total Thyroidectomy

 Kim Seok-Mo  ;  Kim Hyeung Kyoo  ;  Kim Kuk-Jin  ;  Chang Ho Jin  ;  Kim Bup-Woo  ;  Lee Yong Sang  ;  Chang Hang-Seok  ;  Park Cheong Soo 
 THYROID, Vol.25(7) : 830-833, 2015 
Journal Title
Issue Date
Adult ; Aged ; Calcium/blood* ; Cohort Studies ; Female ; Humans ; Hypoparathyroidism/blood* ; Hypoparathyroidism/etiology ; Longitudinal Studies ; Male ; Middle Aged ; Parathyroid Hormone/blood* ; Parathyroidectomy/adverse effects ; Prospective Studies ; Radioimmunoassay ; Recovery of Function ; Thyroid Neoplasms/surgery* ; Thyroidectomy/adverse effects ; Young Adult
BACKGROUND: Permanent hypoparathyroidism after total thyroidectomy is a rare but potentially serious iatrogenic complication. The aim of this study was to investigate the rate of recovery from postoperative, permanent hypoparathyroidism in patients undergoing thyroidectomy without parathyroid autotransplantation. METHODS: This study was a prospective case series with a postoperative follow-up of up to 3 years. We enrolled patients with thyroid cancer who underwent total thyroidectomy with central compartment dissection, with or without lateral neck dissection, and who had postoperative permanent hypoparathyroidism, defined as serum levels of intact parathyroid hormone (PTH) <15 pg/mL for at least 1 year. In the postoperative follow-up period, the serum levels of PTH and calcium were measured regularly. Recovery from permanent hypoparathyroidism was defined as return to normal serum levels of PTH (15-65 pg/mL) and calcium (8.5-10.1 mg/dL) without calcium and/or vitamin D supplementation. RESULTS: In the 1467 patients who underwent total thyroidectomy, 22 presented with permanent postoperative hypoparathyroidism. In 5 of these 22 patients, the PTH levels increased steadily and returned to normal in 27.6±2.9 months, after which supplementation of calcium and vitamin D could be discontinued. CONCLUSIONS: Although recovery from permanent hypoparathyroidism is rare, patients should be monitored for serum PTH levels so that unnecessary treatments such as calcium and vitamin D supplementation can be avoided.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kuk Jin(김국진)
Kim, Bup Woo(김법우) ORCID logo https://orcid.org/0000-0002-1342-9055
Kim, Seok Mo(김석모) ORCID logo https://orcid.org/0000-0001-8070-0573
Kim, Hyung Kyu(김형규)
Park, Cheong Soo(박정수)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chang, Ho Jin(장호진) ORCID logo https://orcid.org/0000-0002-8940-3484
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