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Recovery from Permanent Hypoparathyroidism After Total Thyroidectomy

 Kim Seok-Mo  ;  Kim Hyeung Kyoo  ;  Kim Kuk-Jin  ;  Chang Ho Jin  ;  Kim Bup-Woo  ;  Lee Yong Sang  ;  Chang Hang-Seok  ;  Park Cheong Soo 
 Thyroid, Vol.25(7) : 830-833, 2015 
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BACKGROUND: Permanent hypoparathyroidism after total thyroidectomy is a rare but potentially serious iatrogenic complication. The aim of this study was to investigate the rate of recovery from postoperative, permanent hypoparathyroidism in patients undergoing thyroidectomy without parathyroid autotransplantation. METHODS: This study was a prospective case series with a postoperative follow-up of up to 3 years. We enrolled patients with thyroid cancer who underwent total thyroidectomy with central compartment dissection, with or without lateral neck dissection, and who had postoperative permanent hypoparathyroidism, defined as serum levels of intact parathyroid hormone (PTH) <15 pg/mL for at least 1 year. In the postoperative follow-up period, the serum levels of PTH and calcium were measured regularly. Recovery from permanent hypoparathyroidism was defined as return to normal serum levels of PTH (15-65 pg/mL) and calcium (8.5-10.1 mg/dL) without calcium and/or vitamin D supplementation. RESULTS: In the 1467 patients who underwent total thyroidectomy, 22 presented with permanent postoperative hypoparathyroidism. In 5 of these 22 patients, the PTH levels increased steadily and returned to normal in 27.6±2.9 months, after which supplementation of calcium and vitamin D could be discontinued. CONCLUSIONS: Although recovery from permanent hypoparathyroidism is rare, patients should be monitored for serum PTH levels so that unnecessary treatments such as calcium and vitamin D supplementation can be avoided.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김국진(Kim, Kuk Jin)
김법우(Kim, Bup Woo)
김석모(Kim, Seok Mo) ORCID logo https://orcid.org/0000-0001-8070-0573
김형규(Kim, Hyung Kyu)
박정수(Park, Cheong Soo)
이용상(Lee, Yong Sang) ORCID logo https://orcid.org/0000-0002-8234-8718
장항석(Chang, Hang Seok)
장호진(Chang, Ho Jin)
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