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Cited 19 times in

Time-Dependent Thrombus Resolution After Tissue-Type Plasminogen Activator in Patients With Stroke and Mice

DC FieldValueLanguage
dc.contributor.author이기정-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.contributor.author권일-
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author송동범-
dc.contributor.author유준상-
dc.date.accessioned2016-02-04T11:31:19Z-
dc.date.available2016-02-04T11:31:19Z-
dc.date.issued2015-
dc.identifier.issn0039-2499-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/140613-
dc.description.abstractBACKGROUND AND PURPOSE: We investigated the relationship between the degree of thrombus resolution and the time from stroke onset or thrombus formation to intravenous tissue-type plasminogen activator (tPA) treatment. METHODS: In patients with stroke, we measured thrombus volume on thin-section noncontrast brain computed tomographic scans taken at baseline and 1 hour after tPA administration. We determined the association between the time from symptom onset to tPA treatment and the degree of thrombus resolution. In a C57/BL6 mouse model of FeCl3-induced carotid artery thrombosis, we investigated the effect of tPA administered at different time intervals after thrombus formation, using Doppler-based blood flow measurement. RESULTS: Of 249 patients enrolled, 171 showed thrombus on baseline computed tomography. Thrombus was resolved by ≥50% in 43 patients (25.1%, good volume reduction) and by <50% in 94 patients (55.0%, moderate volume reduction) 1 hour after tPA treatment. In 34 patients (19.9%, nonvolume reduction; either no change or thrombus volume increased), overall thrombus volume increased. The probability of thrombus resolution decreased as the time interval from symptom onset to treatment increased. On multivariate analysis, good volume reduction was independently related with shorter time intervals from symptom onset to tPA treatment (odds ratio, 0.986 per minute saved; 95% confidence interval, 0.974-0.999). In the mouse model, as the interval between thrombus formation and tPA treatment increased, the initiation of recanalization was delayed (P=0.006) and the frequency of final recanalization decreased (P for trends=0.006). CONCLUSIONS: Early administration of tPA after stroke onset is associated with better thrombus resolution.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1877~1882-
dc.relation.isPartOfStroke-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnimals-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSpecies Specificity-
dc.subject.MESHStroke/diagnosis*-
dc.subject.MESHStroke/drug therapy*-
dc.subject.MESHThrombolytic Therapy/trends*-
dc.subject.MESHThrombosis/diagnosis*-
dc.subject.MESHThrombosis/drug therapy*-
dc.subject.MESHTime Factors-
dc.subject.MESHTissue Plasminogen Activator/administration & dosage*-
dc.subject.MESHTreatment Outcome-
dc.titleTime-Dependent Thrombus Resolution After Tissue-Type Plasminogen Activator in Patients With Stroke and Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorSeo Hyun Kim-
dc.contributor.googleauthorEung Yeop Kim-
dc.contributor.googleauthorDongbeom Song-
dc.contributor.googleauthorIl Kwon-
dc.contributor.googleauthorSeung-Hee Yang-
dc.contributor.googleauthorKijeong Lee-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1161/STROKEAHA.114.008247-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02696-
dc.contributor.localIdA04369-
dc.contributor.localIdA00245-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA02017-
dc.contributor.localIdA02513-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02690-
dc.identifier.pmid25967573-
dc.identifier.urlhttp://stroke.ahajournals.org/content/46/7/1877.long-
dc.subject.keyword3D image-
dc.subject.keywordferric chloride-
dc.subject.keywordstroke-
dc.subject.keywordthrombolytic therapy-
dc.subject.keywordthrombosis-
dc.contributor.alternativeNameLee, Ki Jeong-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.alternativeNameKwon, Il-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameSong, Dong Beom-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.affiliatedAuthorLee, Ki Jeong-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKwon, Il-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorSong, Dong Beom-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.rights.accessRightsnot free-
dc.citation.volume46-
dc.citation.number7-
dc.citation.startPage1877-
dc.citation.endPage1882-
dc.identifier.bibliographicCitationStroke, Vol.46(7) : 1877-1882, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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