96 201

Cited 11 times in

Effect of Intraoperative Dexmedetomidine Infusion on Postoperative Bowel Movements in Patients Undergoing Laparoscopic Gastrectomy: A Prospective, Randomized, Placebo-Controlled Study

 Jin Sun Cho  ;  Hyoung-Il Kim  ;  Ki-Young Lee  ;  Ji Yeong An  ;  Sun Joon Bai  ;  Ju Yeon Cho  ;  Young Chul Yoo 
 MEDICINE, Vol.94(24) : 959, 2015 
Journal Title
Issue Date
Adrenergic alpha-2 Receptor Agonists/administration & dosage ; Adrenergic alpha-2 Receptor Agonists/therapeutic use* ; Adult ; Aged ; Dexmedetomidine/administration & dosage ; Dexmedetomidine/therapeutic use* ; Double-Blind Method ; Female ; Gastrectomy/adverse effects* ; Humans ; Ileus/drug therapy* ; Ileus/etiology* ; Intraoperative Care/methods ; Laparoscopy/adverse effects* ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Postoperative Period ; Prospective Studies
Sympathetic hyperactivation is one of the causes of postoperative ileus, which occurs frequently after abdominal surgery and adversely influences the patient's prognosis. We aimed to investigate whether dexmedetomidine (DEX) could attenuate postoperative ileus in patients undergoing laparoscopic gastrectomy. Ninety-two patients were randomized to the control (n = 46) or DEX group (n = 46). DEX was administered at a loading dose of 0.5 μg/kg for 10 minutes, followed by an infusion rate of 0.4 μg/kg/h from insufflation of the pneumoperitoneum to the end of surgery. The primary goal was to compare postoperative bowel movements by evaluating the time to first flatus. The balance of the autonomic nervous system, duration of postoperative hospital stay, and pain scores were assessed. The time to first flatus was shorter in the DEX group compared with the control group (67.2 ± 16.8 hours vs 79.9 ± 15.9 hours, P < 0.001). The low-frequency/high-frequency power ratio during pneumoperitoneum increased in the control group, compared with baseline values and the DEX group. The length of postoperative hospital stay was shorter in the DEX group compared with the control group (5.4 ± 0.7 days vs 5.8 ± 1.1 days, P = 0.04). Patients in the DEX group had lower pain scores and required fewer analgesics at 1 hour postoperatively. DEX facilitated bowel movements and reduced the length of hospital stay in patients undergoing laparoscopic gastrectomy. This may be attributed to the sympatholytic and opioid-sparing effects of DEX.
Files in This Item:
T201502246.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Il(김형일) ORCID logo https://orcid.org/0000-0002-6134-4523
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Lee, Ki Young(이기영) ORCID logo https://orcid.org/0000-0003-4893-3195
Cho, Jin Sun(조진선) ORCID logo https://orcid.org/0000-0002-5408-4188
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.