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Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examination Survey 2011-2012

Authors
 John Hoon Rim  ;  Yong-ho Lee  ;  Bong-Soo Cha  ;  Sang-Guk Lee  ;  Jeong-Ho Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.448 : 74-79, 2015 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2015
MeSH
Albuminuria/blood* ; Female ; Health Surveys* ; Humans ; Male ; Metabolic Syndrome/blood* ; Middle Aged ; Nutrition Surveys* ; Obesity, Abdominal/blood* ; Republic of Korea ; Risk Factors
Keywords
Central obesity ; Metabolic syndrome ; Microalbuminuria
Abstract
BACKGROUND: We investigated the major contributing component of metabolic syndrome (MetS) that results in microalbuminuria (MAU) in the general population as well as in nondiabetic nonhypertensive subjects. METHODS: The study population consisted of a total of 9961 subjects (4429 men and 5532 women) who participated in the Korea National Health and Nutrition Examination Surveys conducted in 2011 and 2012. MAU was defined as a urine albumin-to-creatinine ratio of >3.39mg/mmol. After analyzing the contribution of each five MetS components for the presence of MAU with adjustment for other risk factors in the total population, we further examined the contribution of these components to MAU in the nondiabetic nonhypertensive subpopulation. RESULTS: The most significantly associated factors for MAU in both genders were high blood pressure, followed by impaired fasting glucose, and high triglycerides. In addition, central obesity contributed significantly to MAU only in women. For the nondiabetic nonhypertensive subpopulation, high blood pressure in both genders and central obesity in women were important risk factors for MAU. We suggest two possible hypotheses for the gender different phenomenon. CONCLUSIONS: Central obesity was an independent risk factor for MAU in the general Korean women as well as in the nondiabetic nonhypertensive women.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898115002934
DOI
10.1016/j.cca.2015.06.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Rim, John Hoon(임정훈) ORCID logo https://orcid.org/0000-0001-6825-8479
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140503
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