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Additive beneficial effects of valsartan combined with rosuvastatin in the treatment of hypercholesterolemic hypertensive patients

Authors
 Ji Yong Jang  ;  Sang Hak Lee  ;  Byung Soo Kim  ;  Hong Seog Seo  ;  Woo Shik Kim  ;  Youngkeun Ahn  ;  Nae Hee Lee  ;  Kwang Kon Koh  ;  Tae Soo Kang  ;  Sang Ho Jo  ;  Bum Kee Hong  ;  Jang Ho Bae  ;  Hyoung Mo Yang  ;  Kwang Soo Cha  ;  Bum Soo Kim  ;  Choong Hwan Kwak  ;  Deok Kyu Cho  ;  Ung Kim  ;  Joo Hee Zo  ;  Duk Hyun Kang  ;  Wook Bum Pyun  ;  Kook Jin Chun  ;  June Namgung  ;  Tae Joon Cha  ;  Jae Hyeon Juhn  ;  YeiLi Jung  ;  Yangsoo Jang 
Citation
 Korean Circulation Journal, Vol.45(3) : 225-233, 2015 
Journal Title
 Korean Circulation Journal 
ISSN
 1738-5520 
Issue Date
2015
Abstract
BACKGROUND AND OBJECTIVES: We compared the efficacy and safety of valsartan and rosuvastatin combination therapy with each treatment alone in hypercholesterolemic hypertensive patients. SUBJECTS AND METHODS: Patients who met inclusion criteria were randomized to receive 1 of the following 2-month drug regimens: valsartan 160 mg plus rosuvastatin 20 mg, valsartan 160 mg plus placebo, or rosuvastatin 20 mg plus placebo. The primary efficacy variables were change in sitting diastolic blood pressure (sitDBP) and sitting systolic blood pressure (sitSBP), and percentage change in low-density lipoprotein-cholesterol (LDL-C) in the combination, valsartan, and rosuvastatin groups. Adverse events (AEs) during the study were analyzed. RESULTS: A total of 354 patients were screened and 123 of them were finally randomized. Changes of sitDBP by least squares mean (LSM) were -11.1, -7.2, and -3.6 mm Hg, respectively, and was greater in the combination, as compared to both valsartan (p=0.02) and rosuvastatin (p<0.001). Changes of sitSBP by LSM were -13.2, -10.8, and -4.9 mm Hg, and was greater in the combination, as compared to rosuvastatin (p=0.006) and not valsartan (p=0.42). Percentage changes of LDL-C by LSM were -52, -4, and -47% in each group, and was greater in the combination, as compared to valsartan (p<0.001), similar to rosuvastatin (p=0.16). Most AEs were mild and resolved by the end of the study. CONCLUSION: Combination treatment with valsartan and rosuvastatin exhibited an additive blood pressure-lowering effect with acceptable tolerability, as compared to valsartan monotherapy. Its lipid lowering effect was similar to rosuvatatin monotherapy.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140442
DOI
10.4070/kcj.2015.45.3.225
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이상학(Lee, Sang Hak) ; 장양수(Jang, Yang Soo) ; 장지용(Jang Ji Yong) ; 홍범기(Hong, Bum Kee)
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