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Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications

Authors
 M. Lee  ;  Y.K. Lee  ;  T.J. Jeon  ;  H.S. Chang  ;  B.-W. Kim  ;  Y.S. Lee  ;  C.S. Park  ;  Y.H. Ryu 
Citation
 CLINICAL RADIOLOGY, Vol.70(6) : 638-643, 2015 
Journal Title
 CLINICAL RADIOLOGY 
ISSN
 0009-9260 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aged ; Catheter Ablation/methods ; Female ; Humans ; Iodine Radioisotopes ; Male ; Middle Aged ; Neoplasm, Residual ; Radiopharmaceuticals ; Thyroglossal Cyst/diagnostic imaging ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods ; Tomography, Emission-Computed, Single-Photon/methods* ; Young Adult
Abstract
AIM: To evaluate the frequency of thyroglossal duct remnant (TGDR) uptake on post-therapy (131)I-scintigraphy in thyroid cancer patients, to analyse the rate of persistent TGDR uptake on follow-up combined (131)I-single-photon emission CT/CT (SPECT/CT), and to identify the differential clinical characteristics between patients with positive and negative TGDR uptake on (131)I-SPECT/CT. MATERIALS AND METHODS: A total of 179 patients treated with total thyroidectomy for thyroid cancer were enrolled in the study. At (131)I-whole-body scan (WBS), TGDR uptake was defined as an increase in radioactivity at the midline of the neck versus the thyroid bed. TGDR uptake on (131)I- SPECT/CT was defined as the presence of radioactivity at the expected pathway of the thyroglossal duct without evidence of metastatic foci. Persistent TGDR uptake was confirmed when TGDR uptake on follow-up (131)I-SPECT/CT corresponded to previous TGDR uptake detected by post-therapy (131)I-SPECT/CT. RESULTS: At SPECT/CT, TGDR uptake was noted in 86 of 179 patients. Stimulated thyroglobulin (sTg) levels were significantly higher (p = 0.02) in patients with positive TGDR uptake. Persistent TGDR uptake on follow-up (131)I-SPECT/CT was noted in 15 of 86 patients; sTg levels were significantly higher (p = 0.03) in the patients with persistent TGDR uptake. CONCLUSION: TGDR uptake is frequently visualized on post-therapy (131)I-SPECT/CT images and can be resistant to (131)I ablation. TGDR uptake has the potential to result in an elevation of serum thyroglobulin levels. (131)I-SPECT/CT clarifies TGDR uptake without additional invasive procedures or imaging studies, eliminating confusion among clinicians for managing differentiated thyroid cancer patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009926015000793
DOI
10.1016/j.crad.2015.02.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bup Woo(김법우) ORCID logo https://orcid.org/0000-0002-1342-9055
Park, Cheong Soo(박정수)
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Jeon, Tae Joo(전태주) ORCID logo https://orcid.org/0000-0002-7574-6734
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140360
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