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Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

Authors
 Dong Hyuk Park  ;  Sul A Lee  ;  Hyeon Joo Jeong  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Hyung Jung Oh 
Citation
 YONSEI MEDICAL JOURNAL, Vol.56(2) : 582-585, 2015 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2015
MeSH
Aged ; Antibiotics, Antitubercular/adverse effects* ; Antibiotics, Antitubercular/therapeutic use ; Edema/etiology ; Female ; Humans ; Kidney Function Tests ; Kidney Glomerulus/pathology ; Nausea/etiology ; Nephrosis, Lipoid/chemically induced* ; Nephrosis, Lipoid/pathology ; Proteinuria ; Remission Induction ; Rifampin/adverse effects* ; Rifampin/therapeutic use ; Treatment Outcome ; Tuberculosis, Pleural/drug therapy*
Keywords
Minimal change disease ; rifampicin ; steroid
Abstract
There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.
Files in This Item:
T201501890.pdf Download
DOI
10.3349/ymj.2015.56.2.582
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Park, Dong Hyuk(박동혁)
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Sul A(이슬아)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140339
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